2014
Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9)
Yang M, Clarke S, Mamula M. Isoaspartyl modification of ZAP70 signaling molecule alters T cell responses (555.9). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.555.9.Peer-Reviewed Original ResearchSystemic lupus erythematosusT cell responsesCell responsesT cell immune responsesCell immune responsesAutoreactive immune cellsT cell defectsMajor target organT-cell immunodeficiencyT cell hyperproliferationPIMT-deficient miceProtein L-isoaspartyl methyltransferaseLupus pathologyAutoimmune miceLupus erythematosusImmune toleranceImmune cellsDeficient miceCell immunodeficiencyImmune responseTarget organsT cell signalingImmune systemAutoimmune BCell hyperproliferation
2008
Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus
Yang M, Mamula M. Isoaspartyl Posttranslational Modification In Drug‐Induced Lupus. The FASEB Journal 2008, 22: 668.20-668.20. DOI: 10.1096/fasebj.22.1_supplement.668.20.Peer-Reviewed Original ResearchLupus-inducing drugsDrug-induced lupusT cell hyperproliferationMRL miceCell hyperproliferationOnset of autoantibodiesLupus-prone miceProtein L-isoaspartyl methyltransferaseT cell functionDose-dependent mannerERK 1/2 pathwayAutoimmune responseMultiple sclerosisRheumatoid arthritisLymphocyte functionMurine modelSelf proteinsLupusCell functionMiceDrugsHydralazineIntracellular levelsSpontaneous eventsHyperproliferation