1992
Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G.
Mamula M, Harley J. Anti-Ro autoantibody with cross-reactive binding to the heavy chain of immunoglobulin G. The Yale Journal Of Biology And Medicine 1992, 65: 277-87. PMID: 1290272, PMCID: PMC2589586.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAutoantigensBinding, CompetitiveCattleCross ReactionsCyanogen BromideEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin Fab FragmentsImmunoglobulin Fc FragmentsImmunoglobulin GImmunoglobulin Heavy ChainsLupus Erythematosus, SystemicPeptide FragmentsPrecipitin TestsRabbitsRibonucleoproteinsRNA, Small CytoplasmicConceptsSystemic lupus erythematosusRo antibodiesAutoimmune diseasesCross-reactive bindingSera of patientsAnti-Ro autoantibodiesHeavy chainAnti-Ro seraFragments of IgGRo proteinLupus erythematosusCyanogen bromide digestion fragmentsAntigenic stimulusRo seraPatient seraAutoantibodiesIgGFine specificityImmunologic determinantsRo responseImmunoglobulin GSerumAntibodiesRo particleRabbit serum
1990
The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease.
Mamula M, Jemmerson R, Hardin J. The specificity of human anti-cytochrome c autoantibodies that arise in autoimmune disease. The Journal Of Immunology 1990, 144: 1835-40. PMID: 1689756, DOI: 10.4049/jimmunol.144.5.1835.Peer-Reviewed Original ResearchConceptsC autoantibodiesC antibodyPresence of autoantibodiesConnective tissue diseaseSpecificity of autoantibodiesAntimitochondrial antibodiesAutoantibody responseTissue diseaseAutoimmune diseasesDisease subsetsSm autoantigenPatient seraAutoantibodiesAnimal modelsModel AgAntibodiesDiseaseSpecificityPatientsSLEAutoantigensMicePathologySerumResponse
1989
The Ro ribonucleoprotein particle: Induction of autoantibodies and the detection of Ro RNAs among species
Mamula M, O'Brien C, Harley J, Hardin J. The Ro ribonucleoprotein particle: Induction of autoantibodies and the detection of Ro RNAs among species. Clinical Immunology 1989, 52: 435-446. PMID: 2503280, DOI: 10.1016/0090-1229(89)90158-x.Peer-Reviewed Original ResearchConceptsRo RNAsInduction of autoantibodiesSystemic lupus erythematosusRo particleAnti-Ro autoantibodiesCell linesRabbit cell linesSjogren's syndromeLupus erythematosusHuman autoimmune seraRo seraImmune responseHigh titersAutoantibodiesAutoimmune seraSerumRabbit serumSolid-phase assaysRabbit antibodiesHuman cellsImmunodiffusion studiesSyndromeBovine cell linesTissue extractsPrecipitin line
1987
Implications of anti-Ro/Sjögren's syndrome A antigen autoantibody in normal sera for autoimmunity.
Gaither K, Fox O, Yamagata H, Mamula M, Reichlin M, Harley J. Implications of anti-Ro/Sjögren's syndrome A antigen autoantibody in normal sera for autoimmunity. Journal Of Clinical Investigation 1987, 79: 841-846. PMID: 3546381, PMCID: PMC424215, DOI: 10.1172/jci112892.Peer-Reviewed Original ResearchConceptsRo/SSAAnti-Ro/SSALa/SSBNormal serumAntigen autoantibodiesSjögren's syndromeAnti-Ro/Sjögren's syndromeRo/Sjögren's syndromeHealthy normal donorsSjögren's syndrome autoantibodiesPreexisting immune responseRo/SSA precipitinsTrue autoantibodiesImmune responseNormal donorsAutoantibodiesSyndromeFragments of IgG.Western immunoblotSSA levelsSerumPatientsSensitive assayLow levelsAutoimmunity
1986
The Ro/SSA autoantigen as an immunogen. Some anti-Ro/SSA antibody binds IgG.
Mamula M, Fox O, Yamagata H, Harley J. The Ro/SSA autoantigen as an immunogen. Some anti-Ro/SSA antibody binds IgG. Journal Of Experimental Medicine 1986, 164: 1889-1901. PMID: 3097237, PMCID: PMC2188496, DOI: 10.1084/jem.164.6.1889.Peer-Reviewed Original Research