2006
Increase in intracellular protein modification associated with altered lymphocyte functions in autoimmunity
Yang M, Doyle H, Gee R, Aswad D, Mamula M. Increase in intracellular protein modification associated with altered lymphocyte functions in autoimmunity. The FASEB Journal 2006, 20: a964-a964. DOI: 10.1096/fasebj.20.5.a964-a.Peer-Reviewed Original ResearchT cellsT-cell proliferative defectsLupus-like autoimmunityT cell hyperproliferationAutoimmune miceImmune toleranceAutoimmune responseLupus CD4Peripheral circulationLymphocyte functionAntigen stimulationT lymphocytesThymic selectionB cellsBone marrowCell hyperproliferationHyperproliferative responseAutoimmunityLymphocytesMiceProliferative defectPhysiologic pHNon-enzymatic modificationIsoaspartyl proteinsVivo
2000
Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus
Liang B, Kashgarian M, Sharpe A, Mamula M. Autoantibody Responses and Pathology Regulated by B7-1 and B7-2 Costimulation in MRL/lpr Lupus. The Journal Of Immunology 2000, 165: 3436-3443. PMID: 10975864, DOI: 10.4049/jimmunol.165.6.3436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntigens, CDAntigens, Differentiation, B-LymphocyteAutoantibodiesB7-1 AntigenB7-2 AntigenBiomarkersComplement C3DNAImmunoglobulin GImmunoglobulin IsotypesImmunoglobulin MKidneyLupus NephritisLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearT-LymphocytesConceptsMRL-lpr/lpr miceSystemic lupus erythematosusLpr miceB7-2 costimulationB7-1Autoantibody responseB7-2Murine modelCostimulatory signalsAnti-small nuclear ribonucleoproteinMRL/lpr lupusHuman systemic lupus erythematosusB7-1/B7C3 complement depositionAnti-DNA titersAnti-DNA autoantibodiesWild-type animalsImmunotherapeutic interventionsMemory CD4Lupus erythematosusAutoimmune diseasesAutoimmune pathologyC3 depositsComplement depositionT lymphocytesMolecular mimicry and the role of B lymphocytes in the processing of autoantigens
Liang B, Mamula* M. Molecular mimicry and the role of B lymphocytes in the processing of autoantigens. Cellular And Molecular Life Sciences 2000, 57: 561-568. PMID: 11130456, PMCID: PMC11147036, DOI: 10.1007/pl00000718.Peer-Reviewed Original ResearchConceptsSelf proteinsB lymphocytesAutoimmune T cell responsesT cell responsesT lymphocyte repertoireAutoreactive cellsSelf antigensAutoimmune diseasesElicit autoimmunityT lymphocytesSelf toleranceSelf peptidesImmune systemMolecular mimicryCell responsesLymphocyte repertoireLymphocytesNormal inhabitantPathogenic agentsInappropriate levelsForeign peptidesMolecular mimicsAutoimmunityAutoantigens
1999
T Cell Autoimmunity in Lupus
Mamula M. T Cell Autoimmunity in Lupus. Contemporary Immunology 1999, 202-219. DOI: 10.1007/978-1-59259-703-1_13.Peer-Reviewed Original ResearchSelf antigensLupus autoimmunityImmune systemSpecific immunologic defectsT cell autoimmunityActivation of lymphocytesComponents of immunityCell autoimmunityAutoimmune syndromeImmunologic defectsAutoimmune diseasesPathologic outcomesProne miceUnmanipulated miceForeign antigensT lymphocytesConventional immunizationAutoimmunitySelf tissuesUncommon occurrenceForeign pathogensObvious malfunctionAntigenAberrant responsesExperimental model
1993
Rules for Peptide Presentation by MHC Class II Molecules
Janeway C, Mamula M, Rudensky A. Rules for Peptide Presentation by MHC Class II Molecules. International Reviews Of Immunology 1993, 10: 301-311. PMID: 8294843, DOI: 10.3109/08830189309061705.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complexForeign MHC moleculesMHC class II moleculesClass II moleculesOrgan transplantationT lymphocytesTissue graftMHC moleculesPeptide presentationRejection processHistocompatibility complexGraftTissue cellsUnrelated individualsRapid destructionIndividualsCellsTransplantationLymphocytesMore loci