Role of macrophage lipids in regulating tumoricidal activity
Schlager S, Madden L, Meltzer M, Bara S, Mamula M. Role of macrophage lipids in regulating tumoricidal activity. Cellular Immunology 1983, 77: 52-68. PMID: 6301697, DOI: 10.1016/0008-8749(83)90006-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCholesterolCytotoxicity, ImmunologicLipidsLymphokinesMacrophage ActivationMaleMiceMice, Inbred C3HNeoplasmsProtein BiosynthesisSuperoxidesConceptsM phiTumoricidal activityCellular lipidsTumor cellsTumor cytotoxicityPhagocytic activitySuperoxide releaseTransient increaseMaximal tumoricidal activityPeritoneal M phiFatty acid contentP815 tumor cellsEarly transient increaseRole of cholesterolChol enrichmentTumor target bindingProtein synthesizingProtein synthesisMacrophage lipidsInflammatory functionsCell binding capacityCellular contentControl supernatantsP815 cellsEndogenous levels