2023
β-catenin engages IKZF factors to control lymphopoiesis
Cosgun K, Jumaa H, Robinson M, Xu L, Xiao G, Arce D, Khanduja D, Chan L, Lee J, Schjerven H, Jellusova J, Müschen M. β-catenin engages IKZF factors to control lymphopoiesis. The Journal Of Immunology 2023, 210: 65.09-65.09. DOI: 10.4049/jimmunol.210.supp.65.09.Peer-Reviewed Original ResearchΒ-cateninZinc finger transcription factorFinger transcription factorDramatic nuclear accumulationGSK3β-dependent phosphorylationT cell signalingT cell developmentTCF factorsRepressive complexesTranscriptional controlEnhancer clusterInteractome studiesTranscriptional activationΒ-catenin activationCommon oncogenic driversInhibition of GSK3βTranscription factorsNegative regulationMesenchymal lineagesNuclear accumulationCell deathMYCT-lymphoid malignancyΒ-catenin expressionPromotes Proliferation
2010
Overcoming Drug Resistance In Acute Lymphoblastic Leukemia by Inhibition of CBP/γ-Catenin
Jiang E, Park E, Nguyen C, Yoon J, Hsieh Y, Loh M, Muschen M, Kahn M, Kim Y. Overcoming Drug Resistance In Acute Lymphoblastic Leukemia by Inhibition of CBP/γ-Catenin. Blood 2010, 116: 3264. DOI: 10.1182/blood.v116.21.3264.3264.Peer-Reviewed Original ResearchICG-001 treatmentMedian survival timeICG-001Β-cateninΓ-cateninDose-dependent downregulationSaline control groupAcute lymphoblastic leukemiaSmall molecule specific inhibitorNOD/SCIDReduction of survivinΒ-catenin siRNAReal-time RT-PCRDownregulation of survivinΒ-catenin expressionDecrease of survivinOvercoming Drug ResistanceTime RT-PCRWestern blot analysisPoor prognosisLymphoblastic leukemiaColon cancer cellsSurvival timeShRNA controlXenograft cells