2023
Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression
Ecker V, Brandmeier L, Stumpf M, Giansanti P, Moreira A, Pfeuffer L, Fens M, Lu J, Kuster B, Engleitner T, Heidegger S, Rad R, Ringshausen I, Zenz T, Wendtner C, Müschen M, Jellusova J, Ruland J, Buchner M. Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression. Cell Reports 2023, 42: 113017. PMID: 37792532, DOI: 10.1016/j.celrep.2023.113017.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseChronic lymphocytic leukemiaCLL cellsMitochondrial reactive oxygen speciesChronic lymphocytic leukemia progressionApoptotic cell deathPoor clinical prognosisCLL cell survivalSmall molecule inhibitorsNegative feedback regulationProtein kinaseReactive oxygen speciesMAPK signalingMAPK activityPromising treatment conceptClinical prognosisClinical challengeLymphocytic leukemiaCell survivalAcute activationCell deathDNA damageDUSP6Treatment conceptFeedback regulation
2004
The BCR-ABL1 Kinase Interferes with Pre-B Cell Receptor Signal Transduction in B Cell Precursor Leukemia Cells.
Klein F, Feldhahn N, Wernet P, Müschen M. The BCR-ABL1 Kinase Interferes with Pre-B Cell Receptor Signal Transduction in B Cell Precursor Leukemia Cells. Blood 2004, 104: 1894. DOI: 10.1182/blood.v104.11.1894.1894.Peer-Reviewed Original ResearchPre-B cell receptorReceptor signal transductionSignal transductionVH gene rearrangementsBCR-ABL1 kinase activityPre-B cell receptor (pre-BCR) signalsKinase activityGenome-wide gene expressionReceptor engagementSignal transduction cascadeLeukemia cellsCell receptorAntigen receptor engagementReceptor-dependent signal transductionNovel target geneCell receptor signalingBCR-ABL1 kinaseApoptotic cell deathCell receptor signalsGene rearrangementsCell receptor engagementBCR-ABL1B cell receptorImmature B cellsTarget genes