Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies
Sadras T, Martin M, Kim-Sing L, Cutler J, Lenz G, Knapp A, Ghergus D, Delmotte F, Schleiss C, Korganow A, Soulas-Sprauel P, Chen Z, Pandey A, Weinstock D, Jumaa H, Meffre E, Martin T, Müschen M. Co-Expression of SYK and ZAP70 Subverts Negative B-Cell Selection and Enables Oncogenic Signaling in Multiple B-Cell Malignancies. Blood 2019, 134: 295. DOI: 10.1182/blood-2019-128999.Peer-Reviewed Original ResearchB-cell chronic lymphocytic leukemiaNegative B cell selectionB cellsB-cell malignanciesB cell selectionCo-expressing cellsT cellsBCR-stimulated B cellsZAP70 expressionMultiple B-cell malignanciesLymphoma cellsAutoreactive BCRsCentral tolerance checkpointsCell deathT cell populationsB cell compartmentChronic lymphocytic leukemiaProximity ligation assayB-cell lymphoma cellsMantle cell lymphomaTumor B cellsExpression of ZAP70Human B-cell lymphoma cellsImmature B cellsDevelopment of leukemiaMicroRNA-142 Is an Essential Negative Regulator of B Cell Maturation and Malignant Transformation
Graham N, Wang W, Magilnick N, Lee J, Wang H, Zhang B, Marcucci G, Muschen M, Reyes E, Boldin M. MicroRNA-142 Is an Essential Negative Regulator of B Cell Maturation and Malignant Transformation. The Journal Of Immunology 2019, 202: 53.22-53.22. DOI: 10.4049/jimmunol.202.supp.53.22.Peer-Reviewed Original ResearchMalignant B-cell transformationB cell developmentEμ-myc transgenic miceEssential negative regulatorB cell maturationNegative regulatorB-cell transformationMiR-142Transgenic miceCell developmentCell transformationB-cell lymphoblastic leukemiaCell maturationEarly B cell developmentPrimary B cell developmentEarly B cell progenitorsPre-B cell stageMature B cell compartmentB cell compartmentB cell progenitorsB-cell ontogenesisIL-7 stimulationImmature B cellsLymphoblastic leukemiaCell ontogenesis