2023
CD25 recruits inhibitory phosphatases for feedback control of B-cell receptor signaling
Sun R, Lee J, Robinson M, Kume K, Cosgun K, Chan L, Leveille E, Geng H, Vykunta V, Shy B, Marson A, Meffre E, Müschen M. CD25 recruits inhibitory phosphatases for feedback control of B-cell receptor signaling. The Journal Of Immunology 2023, 210: 154.23-154.23. DOI: 10.4049/jimmunol.210.supp.154.23.Peer-Reviewed Original ResearchAntigen-experienced B cellsB cellsEarly B cell developmentGerminal centersB cell developmentSpontaneous germinal centersCD25 surface expressionAutoreactive B cellsRole of CD25B cell toleranceB-cell receptor signalingB-cell leukemiaB cell receptorAutoantibody productionCD25Cell toleranceGenetic ablationReceptor signalingBCR signalingOncogenic signalingInhibitorySuccessful initiationSignalingNegative selectionAutoimmunity
2015
Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance
Cao Q, Zhao X, Gery S, Chen Z, Deng R, Sun H, Lin D, Zhao Z, Said J, Li Q, Muschen M, Evans R, Koeffler H. Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance. Blood 2015, 126: 1029. DOI: 10.1182/blood.v126.23.1029.1029.Peer-Reviewed Original ResearchB cell toleranceDKO miceB cellsRheumatoid arthritisMultiple sclerosisWT miceCell toleranceSerum anti-nuclear antibodiesHigher serum IgG concentrationsMature recirculating B cellsPeripheral B cell toleranceAnti-nuclear antibodiesPre-B cell numbersWild-type miceSerum IgG concentrationB2 B cellsRecirculating B cellsAdaptive immune systemSplenic B cellsImmune toleranceSevere autoimmunitySjögren's syndromeAutoimmune disordersMassive infiltrationComplement 3