2012
Lineage-Specific Functions of LKB1 in CML and B Lymphoid Blast Crisis
Chan L, Geng H, Muschen M. Lineage-Specific Functions of LKB1 in CML and B Lymphoid Blast Crisis. Blood 2012, 120: 34. DOI: 10.1182/blood.v120.21.34.34.Peer-Reviewed Original ResearchBCR-ABL1LBC cellsImatinib treatmentInactivation of AMPKBlast crisisCancer cellsSolid tumorsB-lymphoid blast crisisHematopoietic stem cellsLKB1 deletionTumor suppressorInitial proliferative burstProgenitor cellsPoor clinical outcomeBone marrow hematopoietic stemAerobic glycolysisB-cell precursor cellsLymphoid blast crisisCML blast crisisTamoxifen-inducible CrePhospho-p70 S6 kinaseHematopoietic stemClinical outcomesRole of LKB1Lymphoblastic leukemia
2000
CD95 ligand expression as a mechanism of immune escape in breast cancer
Müschen M, Moers C, Warskulat U, Even J, Niederacher D, Beckmann M. CD95 ligand expression as a mechanism of immune escape in breast cancer. Immunology 2000, 99: 69-77. PMID: 10651943, PMCID: PMC2327134, DOI: 10.1046/j.1365-2567.2000.00921.x.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBreast NeoplasmsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesEnzyme-Linked Immunosorbent AssayFas Ligand ProteinFas ReceptorFemaleFlow CytometryHumansImmunohistochemistryJurkat CellsLymphocyte CountMembrane GlycoproteinsProtein IsoformsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsBreast cancer cellsT cellsBreast cancerCD95L expressionImmune escapeIFN-gammaCancer cellsJurkat T cellsTumor-infiltrating T cellsCD95L mRNA levelsDepletion of CD4Cultured breast cancer cellsBreast cancer patientsPeripheral blood lymphocytesCD95/CD95L systemBreast cancer cell linesNon-malignant mammary tissuesActivated T cellsCD95 ligand expressionRate of apoptosisBreast cancer sectionsCancer cell linesInteraction of CD95Systemic immunosuppressionCancer patients