2010
Pre-B Cell Receptor Signaling Distinguishes E2A-PBX1 From Other Subtypes of Acute Lymphoblastic Leukemia
Nahar R, Trageser D, Klemm L, Duy C, Hofmann W, Park E, Kim Y, Heisterkamp N, Jumaa H, Muschen M. Pre-B Cell Receptor Signaling Distinguishes E2A-PBX1 From Other Subtypes of Acute Lymphoblastic Leukemia. Blood 2010, 116: 274. DOI: 10.1182/blood.v116.21.274.274.Peer-Reviewed Original ResearchPre-B cell receptorPre-B cell receptor signalingFunctional pre-B cell receptorEarly pre-B cell stageCanonical Wnt/β-catenin signalingPre-B cell stageCell receptor signalingWnt/β-catenin signalingCell receptor functionE2A-PBX1Β-catenin signalingBCR-ABL1 oncogeneCell stageB cell lineage commitmentCell receptorReceptor signalingPre-B cell receptor expressionEarly B cell developmentComparative gene expressionMLL-AF4Pre-B cell receptor functionCell lineage commitmentReceptor functionGene expression differencesCanonical Wnt/β-catenin
2008
The Pre-B Cell Receptor Suppresses Leukemogenesis by Censoring MYC Expression.
Nahar R, Trageser D, Klemm L, Duy C, van Essen P, Kim Y, Heisterkamp N, Martinelli G, Hofmann W, Jack H, Jumaa H, Muschen M. The Pre-B Cell Receptor Suppresses Leukemogenesis by Censoring MYC Expression. Blood 2008, 112: 1918. DOI: 10.1182/blood.v112.11.1918.1918.Peer-Reviewed Original ResearchPre-B cell receptorPre-B cell receptor expressionPre-B cell receptor signalingFunctional pre-B cell receptorEarly pre-B cell stagePre-B cell stageCell receptor signalingSubstantial growth advantageB cell precursorsCell stageE2A-PBX1Receptor signalingCell receptorCell precursorsEarly B cell developmentGrowth advantageComparative gene expressionMYC expressionMLL-AF4Cell receptor expressionB cell developmentMYC mRNA levelsHeavy chain locusHigh expression levelsBCR-ABL1 oncogene