Extrafollicular CD4+ T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation
Deng R, Hurtz C, Yue C, Xiao G, Yu H, Muschen M, Forman S, Martin P, Zeng D. Extrafollicular CD4+ T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation. Blood 2015, 126: 1875. DOI: 10.1182/blood.v126.23.1875.1875.Peer-Reviewed Original ResearchBALB/c recipientsHematopoietic cell transplantationChronic GVHDC recipientsC57BL/6 donorsAllogeneic hematopoietic cell transplantationGC formationImmune-mediated syndromePredominance of IgG1Presence of IgG1Germinal center formationChronic graftJ-graftHost diseaseC57BL/6 recipientsCell transplantationGVHDC57BL/6 graftsDisease inductionSimilar severityGerminal centersB cellsCD4GraftProfound reduction