2007
The Balance between Myc and Bcl6 Determines Self-Renewal or Differentiation of Pre-B Cells.
Duy C, de Alboran I, Jumaa H, Muschen M. The Balance between Myc and Bcl6 Determines Self-Renewal or Differentiation of Pre-B Cells. Blood 2007, 110: 797. DOI: 10.1182/blood.v110.11.797.797.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaBCR-ABL1B cellsDownregulation of MYCImmature B cellsEarly B cell developmentB cell differentiationLymphoblastic leukemiaExpression of MYCB cell developmentNovo expressionLarge B-cell lymphomaBCR-ABL1 inhibitorsB-cell lymphomaGerminal center B cellsB-cell malignanciesDe novo expressionCell lymphomaBone marrowPre-B cell culturesPre B cellsLeukemic transformationInduction of differentiationIL7Expression of BCL6
2000
Defining CD95 as a tumor suppressor gene
Müschen M, Warskulat U, Beckmann M. Defining CD95 as a tumor suppressor gene. Journal Of Molecular Medicine 2000, 78: 312-325. PMID: 11001528, DOI: 10.1007/s001090000112.Peer-Reviewed Original ResearchConceptsTumor suppressor geneSuppressor geneCD95L expressionReceptor-ligand systemCD95L-mediated apoptosisKey regulatorDe novo expressionMalignant cellsGenesSomatic mutationsCD95 geneLymphocyte homeostasisBystander cellsCD95ApoptosisNatural ligandMalignant progressionNonmalignant counterpartsNovo expressionTumor progressionExpressionCellsTumor cellsGermlineAntitumor immunity