VPREB1 Deletions Occur Independent of Lambda-Light Chain Rearrangement and Predict Worse Outcome In Pediatric Acute Lymphoblastic Leukemia (ALL)
Miles R, Downie J, Jahromi M, Joshi D, Rodic V, Muschen M, Yang J, Evans W, Meeker N, Trede N, Frazer J, Barnette P, Schiffman J. VPREB1 Deletions Occur Independent of Lambda-Light Chain Rearrangement and Predict Worse Outcome In Pediatric Acute Lymphoblastic Leukemia (ALL). Blood 2010, 116: 273. DOI: 10.1182/blood.v116.21.273.273.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaLight chain rearrangementB cellsResearch HospitalWorse outcomesSt. Jude Children's Research HospitalCopy number alterationsPediatric acute lymphoblastic leukemiaB-cell developmental genesWorse clinical outcomesClinical risk stratificationSorted B cellsV-J junctionUnderstanding of leukemogenesisHomozygous deletionM2 marrowChain rearrangementClinical outcomesRisk stratificationLymphoblastic leukemiaEnhancer deletionBlood leukocytesHealthy volunteersHispanic ethnicityB cells results