2016
Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments
Teppo S, Mehtonen J, Eldfors S, Heckman C, Müschen M, Heinäniemi M, Lohi O. Transcriptional Regulatory Landscape of TCF3-PBX1-Positive Leukemia and Novel Targeted Treatments. Blood 2016, 128: 4077. DOI: 10.1182/blood.v128.22.4077.4077.Peer-Reviewed Original ResearchTranscriptional regulatory landscapeTranscription factorsRegulatory landscapeCell line modelsFusion proteinGenome-wide mapsGlobal nuclear runNovel long non-coding RNANetwork inference analysisDruggable targetsLong non-coding RNAsGene expression differencesNon-coding RNAsGene Expression OmnibusGRO-seq analysisTumor suppressor genePBX1 functionsNovel drug targetsNascent transcriptionTranscriptional landscapeEnhancer RNAsGenomic regionsGRO-seqNetwork inference algorithmsExpression differences
2010
Pre-B Cell Receptor Signaling Distinguishes E2A-PBX1 From Other Subtypes of Acute Lymphoblastic Leukemia
Nahar R, Trageser D, Klemm L, Duy C, Hofmann W, Park E, Kim Y, Heisterkamp N, Jumaa H, Muschen M. Pre-B Cell Receptor Signaling Distinguishes E2A-PBX1 From Other Subtypes of Acute Lymphoblastic Leukemia. Blood 2010, 116: 274. DOI: 10.1182/blood.v116.21.274.274.Peer-Reviewed Original ResearchPre-B cell receptorPre-B cell receptor signalingFunctional pre-B cell receptorEarly pre-B cell stageCanonical Wnt/β-catenin signalingPre-B cell stageCell receptor signalingWnt/β-catenin signalingCell receptor functionE2A-PBX1Β-catenin signalingBCR-ABL1 oncogeneCell stageB cell lineage commitmentCell receptorReceptor signalingPre-B cell receptor expressionEarly B cell developmentComparative gene expressionMLL-AF4Pre-B cell receptor functionCell lineage commitmentReceptor functionGene expression differencesCanonical Wnt/β-catenin