2015
Extrafollicular CD4+ T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation
Deng R, Hurtz C, Yue C, Xiao G, Yu H, Muschen M, Forman S, Martin P, Zeng D. Extrafollicular CD4+ T and B Interaction Induces Chronic Gvhd in the Absence of Germinal Center Formation. Blood 2015, 126: 1875. DOI: 10.1182/blood.v126.23.1875.1875.Peer-Reviewed Original ResearchBALB/c recipientsHematopoietic cell transplantationChronic GVHDC recipientsC57BL/6 donorsAllogeneic hematopoietic cell transplantationGC formationImmune-mediated syndromePredominance of IgG1Presence of IgG1Germinal center formationChronic graftJ-graftHost diseaseC57BL/6 recipientsCell transplantationGVHDC57BL/6 graftsDisease inductionSimilar severityGerminal centersB cellsCD4GraftProfound reduction
1998
A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.
Josien R, Douillard P, Guillot C, Müschen M, Anegon I, Chetritt J, Menoret S, Vignes C, Soulillou J, Cuturi M. A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. Journal Of Clinical Investigation 1998, 102: 1920-1926. PMID: 9835616, PMCID: PMC509143, DOI: 10.1172/jci4221.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBlood TransfusionGraft Enhancement, ImmunologicGraft RejectionGraft SurvivalHeart TransplantationLeukocytesLymphocyte Culture Test, MixedMaleRatsRats, Inbred BUFRats, Inbred LewRNA, MessengerSpleenTissue DonorsTransforming Growth Factor betaTransplantation, HomologousConceptsAllograft toleranceHeart allograft toleranceNonspecific blood transfusionsProlonged graft survivalTh2-related cytokinesTGF-beta1 mRNALater time pointsGraft survivalAllograft rejectionHeart allograftsImmunological mechanismsBlood transfusionRegulatory cellsDonor-SpecificUnmodified recipientsAdult ratsCritical cytokineStrong infiltrationAllograftsTime pointsRecombinant adenovirusCytokinesGraftRatsLeukocytes