2008
Aberrant Splicing of the SLP65 SH2 Domain Enables Pre-B Cell Transformation and Compromises the Leukemia-Suppressive Function of the Pre-B Cell Receptor
Duy C, Klemm L, Nahar R, van Essen P, Sprangers M, Kim Y, Park E, Martinelli G, Heisterkamp N, Hofmann W, Jumaa H, Muschen M. Aberrant Splicing of the SLP65 SH2 Domain Enables Pre-B Cell Transformation and Compromises the Leukemia-Suppressive Function of the Pre-B Cell Receptor. Blood 2008, 112: 294. DOI: 10.1182/blood.v112.11.294.294.Peer-Reviewed Original ResearchBCR-ABL1Pre-B cell receptorEarly pre-B cell stageCell receptorPre-B cell stageNOD/SCID miceLeukemia cellsPre-B cell receptor signalingSigns of diseaseSplice variantsEarly B cell developmentLeukemic infiltrationQuantitative RT-PCRCell receptor signalingCell receptor engagementSCID miceBone marrowB cell developmentMalignant transformationPre-B-cell transformationLeukemic growthCell transformationInduction of differentiationGermline mutationsMice
2007
The Balance between Myc and Bcl6 Determines Self-Renewal or Differentiation of Pre-B Cells.
Duy C, de Alboran I, Jumaa H, Muschen M. The Balance between Myc and Bcl6 Determines Self-Renewal or Differentiation of Pre-B Cells. Blood 2007, 110: 797. DOI: 10.1182/blood.v110.11.797.797.Peer-Reviewed Original ResearchAcute lymphoblastic leukemiaBCR-ABL1B cellsDownregulation of MYCImmature B cellsEarly B cell developmentB cell differentiationLymphoblastic leukemiaExpression of MYCB cell developmentNovo expressionLarge B-cell lymphomaBCR-ABL1 inhibitorsB-cell lymphomaGerminal center B cellsB-cell malignanciesDe novo expressionCell lymphomaBone marrowPre-B cell culturesPre B cellsLeukemic transformationInduction of differentiationIL7Expression of BCL6