A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance.
Josien R, Douillard P, Guillot C, Müschen M, Anegon I, Chetritt J, Menoret S, Vignes C, Soulillou J, Cuturi M. A critical role for transforming growth factor-beta in donor transfusion-induced allograft tolerance. Journal Of Clinical Investigation 1998, 102: 1920-1926. PMID: 9835616, PMCID: PMC509143, DOI: 10.1172/jci4221.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBlood TransfusionGraft Enhancement, ImmunologicGraft RejectionGraft SurvivalHeart TransplantationLeukocytesLymphocyte Culture Test, MixedMaleRatsRats, Inbred BUFRats, Inbred LewRNA, MessengerSpleenTissue DonorsTransforming Growth Factor betaTransplantation, HomologousConceptsAllograft toleranceHeart allograft toleranceNonspecific blood transfusionsProlonged graft survivalTh2-related cytokinesTGF-beta1 mRNALater time pointsGraft survivalAllograft rejectionHeart allograftsImmunological mechanismsBlood transfusionRegulatory cellsDonor-SpecificUnmodified recipientsAdult ratsCritical cytokineStrong infiltrationAllograftsTime pointsRecombinant adenovirusCytokinesGraftRatsLeukocytes