2016
Role of the transcription factor Ikaros in development of autoimmune disease
Schjerven H, Frietze S, Hai S, Hermiston M, Kogan S, Muschen M. Role of the transcription factor Ikaros in development of autoimmune disease. The Journal Of Immunology 2016, 196: 47.14-47.14. DOI: 10.4049/jimmunol.196.supp.47.14.Peer-Reviewed Original ResearchAnti-nuclear antibodiesAutoimmune diseasesB cellsB cell developmentSerum anti-nuclear antibodiesAuto-reactive B cellsReactive B cellsEx vivo analysisSpleen B cellsEx vivo studySecond signalBCR stimulationEarly B cell developmentRecent genome-wide association studiesVivo analysisMouse modelGenetic predispositionIkaros mutant miceTranscription factor IkarosMouse strainsDiseaseVivo studiesTargeted deletionZinc finger 1Autoimmunity
2015
Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance
Cao Q, Zhao X, Gery S, Chen Z, Deng R, Sun H, Lin D, Zhao Z, Said J, Li Q, Muschen M, Evans R, Koeffler H. Circadian Clock Protein CRY Controls B-Cell Intrinsic Tolerance. Blood 2015, 126: 1029. DOI: 10.1182/blood.v126.23.1029.1029.Peer-Reviewed Original ResearchB cell toleranceDKO miceB cellsRheumatoid arthritisMultiple sclerosisWT miceCell toleranceSerum anti-nuclear antibodiesHigher serum IgG concentrationsMature recirculating B cellsPeripheral B cell toleranceAnti-nuclear antibodiesPre-B cell numbersWild-type miceSerum IgG concentrationB2 B cellsRecirculating B cellsAdaptive immune systemSplenic B cellsImmune toleranceSevere autoimmunitySjögren's syndromeAutoimmune disordersMassive infiltrationComplement 3