2016
Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways
Schjerven H, Ayongaba E, McLaughlin J, Cheng D, Eggesbø L, Lindeman I, Park E, Witte O, Smale S, Frietze S, Muschen M. Analysis of Ikaros tumor suppressor function in BCR-ABL1+ pre-B ALL reveals conserved target genes and biological pathways. The Journal Of Immunology 2016, 196: 122.6-122.6. DOI: 10.4049/jimmunol.196.supp.122.6.Peer-Reviewed Original ResearchTumor suppressor functionTarget genesDevelopmental stage-specific expressionSuppressor functionB cell developmentStem cell signatureZinc fingerHematopoietic developmentIkaros DNAIkaros functionEarly hematopoietic progenitor cellsHematopoietic progenitor cellsRNA sequencingReceptor c-kitMultiple genesBiological functionsInducible expressionTumor suppressionTumor suppressorBiological pathwaysSpecific expressionAdhesion pathwayCritical regulatorIkarosGenes
2015
Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621)
Schjerven H, Eggesbo L, Lindeman I, Muschen M. Ikaros tumor suppressor function in pre-B ALL: potential role of Ikaros target gene Ctnnd1 (IRM10P.621). The Journal Of Immunology 2015, 194: 131.19-131.19. DOI: 10.4049/jimmunol.194.supp.131.19.Peer-Reviewed Original ResearchTumor suppressor functionTarget genesSuppressor functionDNA-binding zinc fingersTumor suppressorGenome-wide expression analysisHuman preZinc finger transcription factorFinger transcription factorIndirect target genesDownstream target genesB cell developmentImportant tumor suppressorRole of IkarosProper hematopoiesisZinc fingerChIP-seqRNA-seqTranscription factorsPatient-derived preExpression analysisPotential roleIkarosGenesIkaros expression