2019
Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia
Hurtz C, Chan LN, Geng H, Ballabio E, Xiao G, Deb G, Khoury H, Chen CW, Armstrong SA, Chen J, Ernst P, Melnick A, Milne T, Müschen M. Rationale for targeting BCL6 in MLL-rearranged acute lymphoblastic leukemia. Genes & Development 2019, 33: 1265-1279. PMID: 31395741, PMCID: PMC6719625, DOI: 10.1101/gad.327593.119.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCell SurvivalCells, CulturedGene DeletionGene Expression Regulation, LeukemicGene TargetingHumansMiceMyeloid-Lymphoid Leukemia ProteinOncogene Proteins, FusionPrecursor Cell Lymphoblastic Leukemia-LymphomaPrognosisPromoter Regions, GeneticProto-Oncogene Proteins c-bcl-6ConceptsB-cell acute lymphoblastic leukemiaAcute lymphoblastic leukemiaLymphoblastic leukemiaPharmacological inhibitionGroup of patientsBCL6 expressionBone marrow biopsyBH3 mimetic ABT-199Transplant recipient miceMLL fusionsB-cell transformationMarrow biopsyTreatment of MLLDismal outcomeRecipient miceNormal B cell developmentImmunohistochemical stainingTranscriptional activationB cell developmentMalignant transformationDrug resistanceGenetic deletionPatient samplesExpression of BimMLL-ENL fusion
1996
Induction of Mouse Embryonal Carcinoma Cell Differentiation and Activation of the Retinoic Acid Receptor β2 Promoter by 1,25-Dihydroxyvitamin D3
Müschen M, Sies H, Schulz W. Induction of Mouse Embryonal Carcinoma Cell Differentiation and Activation of the Retinoic Acid Receptor β2 Promoter by 1,25-Dihydroxyvitamin D3. Biological Chemistry 1996, 377: 703-710. PMID: 8960371, DOI: 10.1515/bchm3.1996.377.11.703.Peer-Reviewed Original ResearchConceptsRAR beta 2 promoterDihydroxyvitamin D3Carcinoma cellsRetinoic acidEffects of calcitriolDb-cAMPRetinoic Acid Receptor β2 PromoterEmbryonal carcinoma cellsCalcitriolRAR betaProtein kinase C. ThereforeInduces differentiationCalcitriol-induced differentiationReporter cell lineMouse embryonal carcinoma cellsDibutyryl cAMPCell linesProtein kinase CCollagen IVEmbryonal carcinoma cell differentiationCarcinoma cell differentiationFunctional TREsBeta-galactosidase activityActivationD3