2012
Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells
Kriegel MA, Rathinam C, Flavell RA. Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 3457-3462. PMID: 22328150, PMCID: PMC3295274, DOI: 10.1073/pnas.1115308109.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityCD11b AntigenCD11c AntigenCD4-Positive T-LymphocytesCell CountChemokine CCL2Dendritic CellsDiabetes Mellitus, Type 1FemaleGene Expression RegulationInsulinIslets of LangerhansLymph NodesMiceMice, Inbred NODMice, TransgenicPromoter Regions, GeneticRatsRecombinant Fusion ProteinsSelf ToleranceConceptsDendritic cellsType 1 diabetesCell infiltrateDiabetes developmentT cellsChemokine CCL2/MCPElevated IL-10 secretionPancreatic isletsCCL2/CCR2 axisCD80/CD86 expressionTransgenic NOD miceVivo transfer systemDendritic cell biologyImmune cell infiltratesIL-10 secretionNonobese diabetic (NOD) miceCCL2/MCPRat insulin promoterUnexpected beneficial roleHypoactive phenotypeLow CD40NOD backgroundPancreatic lymphAutoimmune diabetesNOD mice
2009
E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance
Kriegel MA, Rathinam C, Flavell RA. E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 16770-16775. PMID: 19805371, PMCID: PMC2757842, DOI: 10.1073/pnas.0908957106.Peer-Reviewed Original ResearchConceptsPrimary T cell activationOral toleranceT cellsT cell activationCell activationT helper 1 cellsAntigen-specific strategiesOrgan-specific autoimmunityExperimental allergic encephalitisT cell unresponsivenessElevated baseline levelsNaïve T cellsT cell anergySelf-reactive lymphocytesAnergic T cellsMechanism of actionMyelin basic proteinOral tolerizationSignificant hypersecretionMAP kinases ERK1/2Allergic encephalitisAnergic phenotypeCell unresponsivenessAnergic stateAutoimmune diseases