1994
Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion
Schwartz M, Denninghoff K. Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion. Journal Of Biological Chemistry 1994, 269: 11133-11137. PMID: 7512559, DOI: 10.1016/s0021-9258(19)78101-0.Peer-Reviewed Original ResearchConceptsAlpha 5 beta 1Alpha vBeta 1Intracellular calciumEndothelial cellsAnti-integrin monoclonal antibodiesElevation of intracellularAlpha v integrinsAnti-integrin antibodiesMonoclonal antibodiesV integrinsAntibodiesDistinct intracellularAgonistsIntegrin alpha subunitsAdhesion assaysFunction-blocking anti-integrin antibodiesIntegrinsSpecific integrinsCalciumFibronectinAlpha subunitCellsSame cellsIntracellular
1993
Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.
Schwartz M. Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium. Journal Of Cell Biology 1993, 120: 1003-1010. PMID: 7679387, PMCID: PMC2200079, DOI: 10.1083/jcb.120.4.1003.Peer-Reviewed Original ResearchConceptsCalcium channelsBasal levelsVoltage-independent calcium channelsEndothelial cellsVoltage-dependent calcium channelsIntracellular free calciumElevation of pHiNa-Ca exchangerHuman endothelial cellsBeta 1 integrinIntracellular calciumFura-2Extracellular calciumFree calciumSubunit antibodiesSame antibodyIntracellular pHSteady-state levelsAntibodiesElevationCalciumCellsHigh steady-state levelsInvolvementIntegrins
1991
Multiple integrins share the ability to induce elevation of intracellular pH
Schwartz M, Ingber D, Lawrence M, Springer T, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH. Experimental Cell Research 1991, 195: 533-535. PMID: 1712734, DOI: 10.1016/0014-4827(91)90407-l.Peer-Reviewed Original ResearchConceptsBovine capillary endothelial cellsElevation of pHiAlpha v beta 3Alpha 5 beta 1Capillary endothelial cellsElevation of intracellularT cell receptor complexIntegrin alpha v beta 3Human T lymphocytesPeripheral human T lymphocytesNa-H antiporterCollagen type IIICell receptor complexIntegrin familyT cellsT lymphocytesSignificant elevationIntegrin LFA-1Integrin alpha 5 beta 1LFA-1ICAM-2Endothelial cellsBeta 1Beta 3Antibodies