2021
Developmental origins of mechanical homeostasis in the aorta
Murtada S, Kawamura Y, Li G, Schwartz MA, Tellides G, Humphrey JD. Developmental origins of mechanical homeostasis in the aorta. Developmental Dynamics 2021, 250: 629-639. PMID: 33341996, PMCID: PMC8089041, DOI: 10.1002/dvdy.283.Peer-Reviewed Original ResearchConceptsPostnatal days P2Intramural cellsSmooth muscle contractilityLate prenatal periodBlood pressureDays P2Muscle contractilityAortic structureMurine aortaPrenatal periodEndothelial cellsAortaPathological conditionsAortic developmentDeposition of matrixDevelopmental originsMatrix depositionHomeostasisHomeostatic stateCellsIntramural stressPressure-induced mechanical stressFlow-induced shear stressMechanical loadingContractility
2014
Dysfunctional Mechanosensing in Aneurysms
Humphrey JD, Milewicz DM, Tellides G, Schwartz MA. Dysfunctional Mechanosensing in Aneurysms. Science 2014, 344: 477-479. PMID: 24786066, PMCID: PMC4360903, DOI: 10.1126/science.1253026.Peer-Reviewed Original Research