Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.
Leavesley D, Schwartz M, Rosenfeld M, Cheresh D. Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. Journal Of Cell Biology 1993, 121: 163-170. PMID: 7681432, PMCID: PMC2119781, DOI: 10.1083/jcb.121.1.163.Peer-Reviewed Original ResearchConceptsExtracellular calciumBeta 3Extracellular calcium sourcesAlpha v beta 3Alpha 2 beta 1Absence of cytokinesNa/H antiporterBeta 1 mAbIntracellular calciumCalcium influxIntegrin alpha 2 beta 1Specific influxBeta 1Distinct signaling mechanismsEndothelial cell migrationGrowth factorMeasurable riseDistinct intracellularRespective integrinsH antiporterCellular migrationCell migrationCell contactCalciumMAbsSpreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.
Schwartz M. Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium. Journal Of Cell Biology 1993, 120: 1003-1010. PMID: 7679387, PMCID: PMC2200079, DOI: 10.1083/jcb.120.4.1003.Peer-Reviewed Original ResearchConceptsCalcium channelsBasal levelsVoltage-independent calcium channelsEndothelial cellsVoltage-dependent calcium channelsIntracellular free calciumElevation of pHiNa-Ca exchangerHuman endothelial cellsBeta 1 integrinIntracellular calciumFura-2Extracellular calciumFree calciumSubunit antibodiesSame antibodyIntracellular pHSteady-state levelsAntibodiesElevationCalciumCellsHigh steady-state levelsInvolvementIntegrins