2005
Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*
Katsumi A, Naoe T, Matsushita T, Kaibuchi K, Schwartz MA. Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*. Journal Of Biological Chemistry 2005, 280: 16546-16549. PMID: 15760908, DOI: 10.1074/jbc.c400455200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionEnzyme ActivationEnzyme InhibitorsExtracellular MatrixExtracellular Signal-Regulated MAP KinasesIntegrin alphaVbeta3IntegrinsJNK Mitogen-Activated Protein KinasesLigandsMAP Kinase Kinase 4MiceMitogen-Activated Protein Kinase KinasesNIH 3T3 CellsPhosphatidylinositol 3-KinasesPhosphorylationProtein ConformationSignal TransductionStress, MechanicalTime FactorsConceptsIntegrin activationExtracellular matrix proteinsRole of integrinsConformational activationBiochemical signalsNIH3T3 cellsMolecular mechanismsCellular responsesMatrix proteinsExtracellular matrixCell growthMechanical stretch stimulationIntegrin alphavbeta3IntegrinsMechanical tensionMechanical stretchCritical determinantStretch stimulationActivationPhosphoinositolMechanotransductionJNKProteinApoptosisDifferentiation
2004
Integrins in Mechanotransduction*
Katsumi A, Orr AW, Tzima E, Schwartz MA. Integrins in Mechanotransduction*. Journal Of Biological Chemistry 2004, 279: 12001-12004. PMID: 14960578, DOI: 10.1074/jbc.r300038200.Peer-Reviewed Original Research
1994
Integrins as Signal Transducing Receptors
Schwartz M. Integrins as Signal Transducing Receptors. 1994, 33-47. DOI: 10.1016/b978-0-08-091729-0.50007-3.Peer-Reviewed Original ResearchSignal transducing receptorsExtracellular matrixProtein kinase CCell functionIntracellular second messengerRole of integrinsCytoskeletal organizationInositol lipidsCell shapeSecond messengerKinase CAnchorage-dependent cellsSuch messengersCell typesContact of cellsOnly adhesionIntegrinsMessengerActivation of plateletsCellsCytoskeletonRecent dataReceptorsAdhesionDifferentiation