2009
Suppression of RhoG activity is mediated by a syndecan 4–synectin–RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway
Elfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M. Suppression of RhoG activity is mediated by a syndecan 4–synectin–RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway. Journal Of Cell Biology 2009, 186: 75-83. PMID: 19581409, PMCID: PMC2712988, DOI: 10.1083/jcb.200810179.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsCluster AnalysisEnzyme ActivationFibroblast Growth Factor 2GTP PhosphohydrolasesGuanine Nucleotide Dissociation InhibitorsHeLa CellsHumansMiceMice, KnockoutModels, BiologicalPhosphorylationPhosphoserineProtein Kinase C-alphaRac1 GTP-Binding ProteinRatsRho GTP-Binding ProteinsRho-Specific Guanine Nucleotide Dissociation InhibitorsSyndecan-4ConceptsFibroblast growth factor-2Polarized activationRac1 activationSmall guanosine triphosphatase Rac1Activation pathwayProtein complexesRac activationPlasma membranePhysiological defectsSyndecan-4RhoGDI1Major regulatorInactive stateGrowth factor 2RhoGRhoG activityProteoglycan receptorsEndothelial migrationTernary complexFactor 2Genetic deletionSynectinRac1PKCalphaActivation
2006
Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling
Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling. Molecular Biology Of The Cell 2006, 17: 4686-4697. PMID: 16928957, PMCID: PMC1635406, DOI: 10.1091/mbc.e06-04-0289.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VesselsCattleCyclic AMP-Dependent Protein KinasesEndothelial CellsEnzyme ActivationExtracellular MatrixFibroblast Growth Factor 2FibronectinsIntegrin alpha2beta1Integrin alpha5beta1Integrin alphaVbeta3Models, BiologicalPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesProtein Kinase CSignal TransductionStress, MechanicalTalin
2003
Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis
Hood JD, Frausto R, Kiosses WB, Schwartz MA, Cheresh DA. Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis. Journal Of Cell Biology 2003, 162: 933-943. PMID: 12952943, PMCID: PMC2172815, DOI: 10.1083/jcb.200304105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChick EmbryoEnzyme ActivationFibroblast Growth Factor 2Focal Adhesion Protein-Tyrosine KinasesIntegrin alphaVbeta3IntegrinsMitogen-Activated Protein KinasesNeovascularization, PhysiologicP21-Activated KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene Proteins c-rafRas ProteinsReceptors, VitronectinSignal TransductionSrc-Family KinasesVascular Endothelial Growth Factor AConceptsPathways of angiogenesisC-RafDistinct vascular responsesDownstream of RasUpstream of RasC-Raf activationC-Raf activityKinase-dependent phosphorylationRas-ERK pathwayInhibition of FAKVascular responsesPhosphorylation/activationSignal-related kinaseEndothelial cell survivalSerine 338Blood vesselsRas-ERKActive RAChick chorioallantoic membraneRA activityAngiogenesisERK activityRetroviral deliveryVEGFCell survival