2016
Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia
Baeyens N, Larrivée B, Ola R, Hayward-Piatkowskyi B, Dubrac A, Huang B, Ross TD, Coon BG, Min E, Tsarfati M, Tong H, Eichmann A, Schwartz MA. Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. Journal Of Cell Biology 2016, 214: 807-816. PMID: 27646277, PMCID: PMC5037412, DOI: 10.1083/jcb.201603106.Peer-Reviewed Original ResearchActivin Receptors, Type IIArteriovenous MalformationsArteriovenous Shunt, SurgicalBone Morphogenetic ProteinsCell ProliferationEndoglinEndothelial CellsGene DeletionHEK293 CellsHemorheologyHuman Umbilical Vein Endothelial CellsHumansMechanotransduction, CellularPericytesRegional Blood FlowRetinaSignal TransductionSolubilityStress, MechanicalTelangiectasia, Hereditary Hemorrhagic
2014
Change of Direction in the Biomechanics of Atherosclerosis
Mohamied Y, Rowland EM, Bailey EL, Sherwin SJ, Schwartz MA, Weinberg PD. Change of Direction in the Biomechanics of Atherosclerosis. Annals Of Biomedical Engineering 2014, 43: 16-25. PMID: 25138165, PMCID: PMC4286626, DOI: 10.1007/s10439-014-1095-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAtherosclerosisBiomechanical PhenomenaHemorheologyHumansHydrodynamicsMaleRabbitsConceptsLesion prevalenceEndothelial cellsAnti-inflammatory effectsPro-inflammatory effectsRank correlation coefficientAortic branch ostiaLesion locationRabbit aortaSpearman's rank correlation coefficientArterial systemPrevalenceBranch ostiumConfidence intervalsMature rabbitsAtherosclerosisTime-averaged wall shear stressAgeShear metrics
2012
A novel in vitro flow system for changing flow direction on endothelial cells
Wang C, Lu H, Schwartz MA. A novel in vitro flow system for changing flow direction on endothelial cells. Journal Of Biomechanics 2012, 45: 1212-1218. PMID: 22386042, PMCID: PMC3327813, DOI: 10.1016/j.jbiomech.2012.01.045.Peer-Reviewed Original Research
2009
The Subendothelial Extracellular Matrix Modulates JNK Activation by Flow
Hahn C, Orr AW, Sanders JM, Jhaveri KA, Schwartz MA. The Subendothelial Extracellular Matrix Modulates JNK Activation by Flow. Circulation Research 2009, 104: 995-1003. PMID: 19286608, PMCID: PMC2702158, DOI: 10.1161/circresaha.108.186486.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EAtherosclerosisBasement MembraneCattleCell Culture TechniquesCells, CulturedCollagenDisease Models, AnimalEndothelial CellsEnzyme ActivationExtracellular MatrixFibronectinsHemorheologyInflammationIntegrinsJNK Mitogen-Activated Protein KinasesMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase KinasesOscillometryP21-Activated KinasesPhosphorylationRegional Blood FlowStress, Mechanical