2008
Regulation of LKB1/STRAD Localization and Function by E-Cadherin
Sebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA. Regulation of LKB1/STRAD Localization and Function by E-Cadherin. Current Biology 2008, 19: 37-42. PMID: 19110428, PMCID: PMC2773019, DOI: 10.1016/j.cub.2008.11.033.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Vesicular TransportAdherens JunctionsAMP-Activated Protein Kinase KinasesAMP-Activated Protein KinasesBlotting, WesternCaco-2 CellsCadherinsCell FractionationDNA PrimersFluorescence Resonance Energy TransferHumansMultiprotein ComplexesPhosphorylationProtein Serine-Threonine KinasesReverse Transcriptase Polymerase Chain ReactionConceptsAdherens junctionsLKB1 complexE-cadherinE-cadherin-mediated adherens junctionsAMPK phosphorylationEpithelial apicobasal polarityCell-matrix contactsCell energy metabolismPseudokinase STRADLKB1 kinaseProtein MO25Apicobasal polarityEpithelial polarityCellular processesFluorescence resonance energy transferFamily kinasesKinase activityTumor suppressionTumor suppressorResonance energy transferKinaseUpstream factorsEnergy metabolismSTRADEpithelial cells
2005
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress
Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H, Schwartz MA. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress. Nature 2005, 437: 426-431. PMID: 16163360, DOI: 10.1038/nature03952.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CDCadherinsCattleCell AdhesionCells, CulturedEndothelial CellsFemaleGene DeletionMechanotransduction, CellularMiceMice, KnockoutMultiprotein ComplexesNF-kappa BPlatelet Endothelial Cell Adhesion Molecule-1RatsStress, MechanicalVascular Endothelial Growth Factor Receptor-2ConceptsDownstream inflammatory genesPECAM-1 knockout miceVascular endothelial cell cadherinVascular remodellingHigh-affinity stateInflammatory genesNF-κBVascular homeostasisEndothelial cell responsesCell responsesMechanosensory complexPECAM-1Heterologous cellsPathway upstreamCardiac developmentIntegrin activationAtherogenesisMechanism of transductionPathwayMice