2001
Ligation of Integrin α3β1 by Laminin 5 at the Wound Edge Activates Rho-dependent Adhesion of Leading Keratinocytes on Collagen*
Nguyen B, Ren X, Schwartz M, Carter W. Ligation of Integrin α3β1 by Laminin 5 at the Wound Edge Activates Rho-dependent Adhesion of Leading Keratinocytes on Collagen*. Journal Of Biological Chemistry 2001, 276: 43860-43870. PMID: 11571278, DOI: 10.1074/jbc.m103404200.Peer-Reviewed Original ResearchConceptsHuman foreskin keratinocytesLaminin-5Wound edgeCultured human foreskin keratinocytesRho-independent mechanismEndogenous laminin-5Collagen adhesionSpreading of keratinocytesTransition of keratinocytesForeskin keratinocytesDermal collagenKeratinocytesIntegrin α3β1Wound cellsActivation signalsQuiescent keratinocytesCollagenIntegrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
Jalali S, del Pozo M, Chen K, Miao H, Li Y, Schwartz M, Shyy J, Chien S. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1042-1046. PMID: 11158591, PMCID: PMC14705, DOI: 10.1073/pnas.98.3.1042.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAntigens, CDCells, CulturedCollagenEndothelium, VascularExtracellular MatrixExtracellular Matrix ProteinsFibrinogenFibronectinsHumansIntegrin beta1Integrin beta3IntegrinsJNK Mitogen-Activated Protein KinasesLamininLigandsMitogen-Activated Protein KinasesPlatelet Membrane GlycoproteinsProteinsReceptors, VitronectinShc Signaling Adaptor ProteinsSignal TransductionSrc Homology 2 Domain-Containing, Transforming Protein 1Stress, MechanicalUmbilical VeinsVitronectin
1991
Multiple integrins share the ability to induce elevation of intracellular pH
Schwartz M, Ingber D, Lawrence M, Springer T, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH. Experimental Cell Research 1991, 195: 533-535. PMID: 1712734, DOI: 10.1016/0014-4827(91)90407-l.Peer-Reviewed Original ResearchConceptsBovine capillary endothelial cellsElevation of pHiAlpha v beta 3Alpha 5 beta 1Capillary endothelial cellsElevation of intracellularT cell receptor complexIntegrin alpha v beta 3Human T lymphocytesPeripheral human T lymphocytesNa-H antiporterCollagen type IIICell receptor complexIntegrin familyT cellsT lymphocytesSignificant elevationIntegrin LFA-1Integrin alpha 5 beta 1LFA-1ICAM-2Endothelial cellsBeta 1Beta 3Antibodies