Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice
Tran J, Muench M, Gaillard B, Darst O, Tomayko M, Jackman R. Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice. Frontiers In Immunology 2023, 14: 1281130. PMID: 38146372, PMCID: PMC10749330, DOI: 10.3389/fimmu.2023.1281130.Peer-Reviewed Original ResearchConceptsB cell responsesPlatelet transfusionsMajor histocompatibility complexCell responsesPrior exposurePlatelet alloimmunizationMemory B cell responsesPlatelet transfusion recipientsSubsequent platelet transfusionsAllogeneic platelet transfusionsNegative bacterial infectionsPolyinosinic-polycytidylic acidGerminal center formationPrior inflammationAlloantibody responsesAlloimmune responsePlatelet refractorinessFuture transplantTransfusion recipientsMHC tetramersAdverse reactionsInflammatory environmentAntigen experiencePlatelet antigensTransfusionEnhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice
Jackman R, Darst O, Gaillard B, Tran J, Tomayko M, Muench M. Enhanced alloresponse to platelet transfusion due to immune dysregulation following ablative chemotherapy in mice. Frontiers In Immunology 2023, 14: 1281123. PMID: 38090570, PMCID: PMC10711281, DOI: 10.3389/fimmu.2023.1281123.Peer-Reviewed Original ResearchConceptsAblative chemotherapyAlloantibody responsesPlatelet transfusionsB cellsPotent immunological effectsT cell responsesImpact of chemotherapyTransitional B cellsAllogeneic platelet transfusionsRisk of alloimmunizationNon-specific activationSubsequent transfusionsAllogeneic plateletsLymphocyte depletionBlood transfusionImmune dysregulationPlatelet recipientsSerum levelsPatient populationImmunological effectsImmunological environmentTransfusionRejection of transplantsChemotherapyHealthy people