2023
Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice
Tran J, Muench M, Gaillard B, Darst O, Tomayko M, Jackman R. Polyinosinic: polycytidylic acid induced inflammation enhances while lipopolysaccharide diminishes alloimmunity to platelet transfusion in mice. Frontiers In Immunology 2023, 14: 1281130. PMID: 38146372, PMCID: PMC10749330, DOI: 10.3389/fimmu.2023.1281130.Peer-Reviewed Original ResearchConceptsB cell responsesPlatelet transfusionsMajor histocompatibility complexCell responsesPrior exposurePlatelet alloimmunizationMemory B cell responsesPlatelet transfusion recipientsSubsequent platelet transfusionsAllogeneic platelet transfusionsNegative bacterial infectionsPolyinosinic-polycytidylic acidGerminal center formationPrior inflammationAlloantibody responsesAlloimmune responsePlatelet refractorinessFuture transplantTransfusion recipientsMHC tetramersAdverse reactionsInflammatory environmentAntigen experiencePlatelet antigensTransfusion
2017
B Cell Biology
Sadanand S, Tomayko M. B Cell Biology. 2017, 97-119. DOI: 10.1007/978-3-319-29785-9_7.ChaptersB cell biologyCell biologyB cellsImmune responseEffector functionsB cell-T cell interactionsCell-T cell interactionsB cell developmentCurrent therapeutic mechanismsRegulatory B cellsB-cell depletionB cell responsesAdaptive immune responsesMemory B cellsGerminal center responseEstablishment of toleranceCell developmentCentral playerProtective immunityCell depletionDurable immunityAntigenic targetsAntibody isotypesPlasma cellsTherapeutic mechanism
2014
CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence
Conter LJ, Song E, Shlomchik MJ, Tomayko MM. CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence. PLOS ONE 2014, 9: e92009. PMID: 24664100, PMCID: PMC3963874, DOI: 10.1371/journal.pone.0092009.Peer-Reviewed Original ResearchConceptsMurine memory B cellsPlasma cellsCD73 expressionBone marrow (BM) PCsB cellsCell responsesDependent B cell responsesBone marrow plasma cellsFollicular helper cellsT cell responsesB cell responsesMemory B cellsMarrow plasma cellsWild-type miceGerminal center B cellsCD73 knockout miceEarly secondary responseHelper cellsHumoral immunityT lymphocytesPC compartmentAdenosine signalingType miceGerminal centersKnockout mice