2014
CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence
Conter LJ, Song E, Shlomchik MJ, Tomayko MM. CD73 Expression Is Dynamically Regulated in the Germinal Center and Bone Marrow Plasma Cells Are Diminished in Its Absence. PLOS ONE 2014, 9: e92009. PMID: 24664100, PMCID: PMC3963874, DOI: 10.1371/journal.pone.0092009.Peer-Reviewed Original ResearchConceptsMurine memory B cellsPlasma cellsCD73 expressionBone marrow (BM) PCsB cellsCell responsesDependent B cell responsesBone marrow plasma cellsFollicular helper cellsT cell responsesB cell responsesMemory B cellsMarrow plasma cellsWild-type miceGerminal center B cellsCD73 knockout miceEarly secondary responseHelper cellsHumoral immunityT lymphocytesPC compartmentAdenosine signalingType miceGerminal centersKnockout mice
2008
BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact
Scholz JL, Crowley JE, Tomayko MM, Steinel N, O'Neill PJ, Quinn WJ, Goenka R, Miller JP, Cho YH, Long V, Ward C, Migone TS, Shlomchik MJ, Cancro MP. BLyS inhibition eliminates primary B cells but leaves natural and acquired humoral immunity intact. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 15517-15522. PMID: 18832171, PMCID: PMC2563088, DOI: 10.1073/pnas.0807841105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationB-Cell Activating FactorB-LymphocytesFemaleImmunity, InnateImmunologic MemoryMiceMice, Inbred C57BLConceptsMemory B cellsAntibody-secreting cellsB cellsImmune responseAntigen-experienced B cellsSecondary immune responsePrimary immune responseB cell numbersPeritoneal B1 cellsHumoral immunityPrimary B cellsPlasma cellsB1 cellsNaïve cellsCell numberMemory poolMemory cellsCellsCytokinesIgMImmunityPreimmuneAntibodiesBLySResponse