2023
P13-029-23 Cross-Sectional Associations of Serum Fatty Acids and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy
Melink Z, Schnell P, Ormiston K, Weinhold K, Kopec R, Lustberg M, Orchard T. P13-029-23 Cross-Sectional Associations of Serum Fatty Acids and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy. Current Developments In Nutrition 2023, 7: 100485. DOI: 10.1016/j.cdnut.2023.100485.Peer-Reviewed Original Research
2022
The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients
Bennouna D, Orchard T, Lustberg M, Kopec R. The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients. Current Developments In Nutrition 2022, 6: 6009237. PMCID: PMC9193887, DOI: 10.1093/cdn/nzac052.004.Peer-Reviewed Original ResearchPlasma concentrationsCognitive impairmentLong-term cognitive impairmentNutritional targetsDocosahexaenoic acidNervonic acidEicosapentaenoic acidOmega-3 fatty acidsNeo-adjuvant chemotherapyBreast cancer patientsEffect of chemotherapyBreast cancer chemotherapyFatty acidsBreast cancer treatmentHippocampal concentrationsDietary interventionSolid tumor treatmentCancer patientsChemotherapy treatmentFatty acid concentrationsObjective biomarkersBreast cancerImpact of visitsChemotherapyMead acid
2021
Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy
Ormiston K, Gaudier-Diaz MM, TinKai T, Fitzgerald J, Cole RM, Andridge R, Lustberg M, DeVries AC, Orchard T. Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy. Nutritional Neuroscience 2021, 25: 2650-2658. PMID: 34772330, PMCID: PMC9095756, DOI: 10.1080/1028415x.2021.1998296.Peer-Reviewed Original ResearchConceptsAlpha-linolenic acidDietary alpha-linolenic acidBrain PUFAsMouse modelDocosahexaenoic acidEicosapentaenoic acidLiver PUFABrain nOmega-3 fatty acidsChemotherapy-treated miceHigh ALA dietLow ALA intakeBrain fatty acidsUseful surrogate markerFatty acidsLiver docosahexaenoic acidToxic side effectsLiver fatty acidALA intakeNeurotrophic markersALA dietDHA dietSurrogate markerLower brainSide effectsChanges in Inflammatory Markers and Correlations with Serum Polyunsaturated Fatty Acids In Postmenopausal Women With Breast Cancer Undergoing Chemotherapy
Zhang Z, Ormiston K, Weinhold K, Schnell P, Kopec R, Lustberg M, Orchard T. Changes in Inflammatory Markers and Correlations with Serum Polyunsaturated Fatty Acids In Postmenopausal Women With Breast Cancer Undergoing Chemotherapy. Journal Of The Academy Of Nutrition And Dietetics 2021, 121: a18. DOI: 10.1016/j.jand.2021.06.034.Peer-Reviewed Original ResearchErythrocyte Long-Chain ω-3 Fatty Acids Are Positively Associated with Lean Mass and Grip Strength in Women with Recent Diagnoses of Breast Cancer
Belury MA, Cole RM, Andridge R, Keiter A, Raman SV, Lustberg MB, Kiecolt-Glaser JK. Erythrocyte Long-Chain ω-3 Fatty Acids Are Positively Associated with Lean Mass and Grip Strength in Women with Recent Diagnoses of Breast Cancer. Journal Of Nutrition 2021, 151: 2125-2133. PMID: 34036350, PMCID: PMC8349126, DOI: 10.1093/jn/nxab109.Peer-Reviewed Original ResearchConceptsPostprandial energy metabolismGrip strengthAppendicular lean massBreast cancerLean massCardiorespiratory fitnessCancer stageTest mealCancer treatmentPostprandial substrate metabolismBreast cancer survivorsLong-chain omega-3Risk of mortalityFat test mealALM/BMIFatty acidsLong chain ωCross-sectional analysisEnergy metabolismLCn-3PUFACancer survivorsCancer patientsMetabolic outcomesRecent diagnosisSame visitChanges in Serum Fatty Acids and Inflammatory Markers in Postmenopausal Women With Breast Cancer Following Chemotherapy Treatment
Zhang Z, Ormiston K, Schnell P, Kopec R, Lustberg M, Orchard T. Changes in Serum Fatty Acids and Inflammatory Markers in Postmenopausal Women With Breast Cancer Following Chemotherapy Treatment. Current Developments In Nutrition 2021, 5: 5140290. PMCID: PMC8182042, DOI: 10.1093/cdn/nzab036_032.Peer-Reviewed Original ResearchSerum fatty acidsInflammatory markersInterleukin-6Breast cancerSerum cytokinesPostmenopausal breast cancer patientsSerum inflammatory markersBreast cancer survivorsBreast cancer patientsFatty acidsMethods Serum samplesTumor necrosis factorTotal monounsaturated FAsTotal monounsaturated fatty acidsEnzyme-linked immunoassaySerum FCytokine changesPostmenopausal womenInflammatory profileCancer survivorsInflammatory stateCancer patientsIL-8Chemotherapy treatmentNecrosis factor
2020
Associations of Long Chain Polyunsaturated Fatty Acid Biomarkers with Affective Symptoms and Cognition in Women Beginning Chemotherapy for Breast Cancer
Zhang Z, Ormiston K, Orchard T, Lustberg M, Schnell P. Associations of Long Chain Polyunsaturated Fatty Acid Biomarkers with Affective Symptoms and Cognition in Women Beginning Chemotherapy for Breast Cancer. Current Developments In Nutrition 2020, 4: nzaa044_065. PMCID: PMC7257812, DOI: 10.1093/cdn/nzaa044_065.Peer-Reviewed Original ResearchSerum fatty acidsNon-significant trendBreast cancerState-Trait Anxiety InventoryAffective symptomsDouble-blinded randomized studyLong-chain omega-3 fatty acidsOmega-3 fatty acidsBaseline fatty acidsSerum FA profilesBreast cancer patientsFatty acidsResults Preliminary resultsRandomized studySerum levelsCancer patientsEffects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy
Ormiston K, Phuwamongkolwiwat-Chu P, Fitzgerald J, Tinkai T, Lustberg M, DeVries A, Andridge R, Orchard T. Effects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy. Current Developments In Nutrition 2020, 4: nzaa057_044. PMCID: PMC7257389, DOI: 10.1093/cdn/nzaa057_044.Peer-Reviewed Original ResearchAnxiety-like behaviorBrain AADietary eicosapentaenoic acidHigh-sucrose dietDHA dietSerum insulinDocosahexaenoic acidOmega-3Low omega-3Eicosapentaenoic acidChemotherapy injectionsInsulin resistanceMouse modelGlucose metabolismSucrose dietOmega-3 fatty acidsBrain fatty acidsHomeostatic model assessmentLower HOMA-IRDiet fed miceHigher serum insulinOvariectomized mouse modelFatty acidsOvariectomized C57BL/6 miceMore anxiety-like behavior
2019
An omega-3 Fatty Acid Enriched Diet Reduces Anxiety-like Behavior While High Dietary Sucrose During Chemotherapy Increases Anxiety-like Behavior in Mice (P14-023-19)
Ormiston K, Orchard T, DeVries A, Phuwamongkolwiwat P, Li J, Andridge R, Fitzgerald J, Tinkai T, Lustberg M. An omega-3 Fatty Acid Enriched Diet Reduces Anxiety-like Behavior While High Dietary Sucrose During Chemotherapy Increases Anxiety-like Behavior in Mice (P14-023-19). Current Developments In Nutrition 2019, 3: nzz052.p14-023-19. PMCID: PMC6573952, DOI: 10.1093/cdn/nzz052.p14-023-19.Peer-Reviewed Original ResearchAnxiety-like behaviorDocosahexaenoic acidIncreases Anxiety-Like BehaviorWeeks of dietBreast cancer patientsAssociation of cytokinesNumber of marblesOvariectomized C57BL/6 miceLess anxiety-like behaviorSignificant differencesSymptoms of anxietyChemotherapy injectionsChemotherapy groupDHA groupHealthy womenFatty acidsMice fedSaline groupC57BL/6 miceInflammatory cytokinesCancer patientsChemotherapy increasesInterleukin-6Results TwentyMouse model
2018
Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women’s Health Initiative
Krok-Schoen J, Brasky T, Hunt R, Rohan T, Baker T, Li W, Carbone L, Mackey R, Snetselaar L, Lustberg M, Neuhouser M. Dietary Long-Chain n-3 Fatty Acid Intake and Arthritis Risk in the Women’s Health Initiative. Journal Of The Academy Of Nutrition And Dietetics 2018, 118: 2057-2069. PMID: 29921541, PMCID: PMC6204099, DOI: 10.1016/j.jand.2018.04.005.Peer-Reviewed Original ResearchConceptsArthritis riskRA riskPostmenopausal womenWomen's Health Initiative Observational StudyHealth initiativesDietary long chain nClinical trial cohortProspective cohort studyFood frequency questionnairePrevalence of arthritisFatty acid intakeWomen's Health InitiativeCox regression modelAnti-inflammatory propertiesFatty acidsHistory of arthritisEvidence of benefitRheumatoid arthritis riskLong chain nArthritis outcomesCohort studyFrequency questionnaireHazard ratioIncident osteoarthritisTrial cohort
2017
Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain
Lustberg M, Orchard T, Reinbolt R, Andridge R, Pan X, Belury M, Cole R, Logan A, Layman R, Ramaswamy B, Wesolowski R, Berger M, Patterson E, Loprinzi C, Shapiro C, Yee L. Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain. Breast Cancer Research And Treatment 2017, 167: 709-718. PMID: 29101597, PMCID: PMC5809189, DOI: 10.1007/s10549-017-4559-z.Peer-Reviewed Original ResearchConceptsQuality of lifeJoint symptomsRandomized placebo-controlled pilot trialBrief Pain Inventory-Short FormPostmenopausal breast cancer patientsRed blood cell (RBC) nPlacebo-controlled pilot trialFACT-ES scoresPlacebo-controlled studyPain severity scoreBreast cancer survivorsBreast cancer patientsAnti-inflammatory propertiesAdjuvant AICommon toxicitiesFACT-ESPurposeAromatase inhibitorsPrimary endpointDrug adherencePill countSecondary outcomesMusculoskeletal painTreatment armsCancer survivorsFatty acids
2015
Effects of Sucrose and Omega-3 Fatty Acids on Chemotherapy-Induced Neuroinflammation in a Mouse Model of Breast Cancer
Gaudier-Diaz M, Lustberg M, Cole R, Belury M, DeVries A, Orchard T. Effects of Sucrose and Omega-3 Fatty Acids on Chemotherapy-Induced Neuroinflammation in a Mouse Model of Breast Cancer. Journal Of The Academy Of Nutrition And Dietetics 2015, 115: a25. DOI: 10.1016/j.jand.2015.06.081.Peer-Reviewed Original Research