2022
The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients
Bennouna D, Orchard T, Lustberg M, Kopec R. The Effects of Chemotherapy on Circulating Plasma Omega-9, Omega-3 Fatty Acids and Plasmalogen in Breast Cancer Patients. Current Developments In Nutrition 2022, 6: 6009237. PMCID: PMC9193887, DOI: 10.1093/cdn/nzac052.004.Peer-Reviewed Original ResearchPlasma concentrationsCognitive impairmentLong-term cognitive impairmentNutritional targetsDocosahexaenoic acidNervonic acidEicosapentaenoic acidOmega-3 fatty acidsNeo-adjuvant chemotherapyBreast cancer patientsEffect of chemotherapyBreast cancer chemotherapyFatty acidsBreast cancer treatmentHippocampal concentrationsDietary interventionSolid tumor treatmentCancer patientsChemotherapy treatmentFatty acid concentrationsObjective biomarkersBreast cancerImpact of visitsChemotherapyMead acid
2021
Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy
Ormiston K, Gaudier-Diaz MM, TinKai T, Fitzgerald J, Cole RM, Andridge R, Lustberg M, DeVries AC, Orchard T. Effects of plant-based versus marine-based omega-3 fatty acids and sucrose on brain and liver fatty acids in a mouse model of chemotherapy. Nutritional Neuroscience 2021, 25: 2650-2658. PMID: 34772330, PMCID: PMC9095756, DOI: 10.1080/1028415x.2021.1998296.Peer-Reviewed Original ResearchConceptsAlpha-linolenic acidDietary alpha-linolenic acidBrain PUFAsMouse modelDocosahexaenoic acidEicosapentaenoic acidLiver PUFABrain nOmega-3 fatty acidsChemotherapy-treated miceHigh ALA dietLow ALA intakeBrain fatty acidsUseful surrogate markerFatty acidsLiver docosahexaenoic acidToxic side effectsLiver fatty acidALA intakeNeurotrophic markersALA dietDHA dietSurrogate markerLower brainSide effects
2020
Effects of Omega-3 Fatty Acids on Insulin Resistance in an Ovariectomized Mouse Model of Diet-Induced Obesity Treated with Chemotherapy
Ormiston K, Zhang Z, Murphy K, DeVries A, Lustberg M, Andridge R, Orchard T. Effects of Omega-3 Fatty Acids on Insulin Resistance in an Ovariectomized Mouse Model of Diet-Induced Obesity Treated with Chemotherapy. Current Developments In Nutrition 2020, 4: nzaa044_044. PMCID: PMC7257328, DOI: 10.1093/cdn/nzaa044_044.Peer-Reviewed Original ResearchInsulin resistanceLF groupBody weightBlood glucoseHF dietHF groupBody fatHigh-fat diet-induced insulin resistanceOmega-3 fatty acidsDiet-induced insulin resistanceLF diet groupHomeostatic model assessmentHOMA-IR scoreDiet-Induced ObesityOvariectomized mouse modelDiet-fed miceLow-fat dietHigh-fat dietLower body weightPercent body fatFasted blood glucoseLower scoresChemotherapy injectionsConclusion ChemotherapySerum insulinAssociations of Long Chain Polyunsaturated Fatty Acid Biomarkers with Affective Symptoms and Cognition in Women Beginning Chemotherapy for Breast Cancer
Zhang Z, Ormiston K, Orchard T, Lustberg M, Schnell P. Associations of Long Chain Polyunsaturated Fatty Acid Biomarkers with Affective Symptoms and Cognition in Women Beginning Chemotherapy for Breast Cancer. Current Developments In Nutrition 2020, 4: nzaa044_065. PMCID: PMC7257812, DOI: 10.1093/cdn/nzaa044_065.Peer-Reviewed Original ResearchSerum fatty acidsNon-significant trendBreast cancerState-Trait Anxiety InventoryAffective symptomsDouble-blinded randomized studyLong-chain omega-3 fatty acidsOmega-3 fatty acidsBaseline fatty acidsSerum FA profilesBreast cancer patientsFatty acidsResults Preliminary resultsRandomized studySerum levelsCancer patientsEffects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy
Ormiston K, Phuwamongkolwiwat-Chu P, Fitzgerald J, Tinkai T, Lustberg M, DeVries A, Andridge R, Orchard T. Effects of Omega-3 Fatty Acids on Brain Fatty Acids and Associations with Glucose Metabolism and Anxiety-Like Behavior in an Ovariectomized Mouse Model of Chemotherapy. Current Developments In Nutrition 2020, 4: nzaa057_044. PMCID: PMC7257389, DOI: 10.1093/cdn/nzaa057_044.Peer-Reviewed Original ResearchAnxiety-like behaviorBrain AADietary eicosapentaenoic acidHigh-sucrose dietDHA dietSerum insulinDocosahexaenoic acidOmega-3Low omega-3Eicosapentaenoic acidChemotherapy injectionsInsulin resistanceMouse modelGlucose metabolismSucrose dietOmega-3 fatty acidsBrain fatty acidsHomeostatic model assessmentLower HOMA-IRDiet fed miceHigher serum insulinOvariectomized mouse modelFatty acidsOvariectomized C57BL/6 miceMore anxiety-like behavior
2015
Effects of Sucrose and Omega-3 Fatty Acids on Chemotherapy-Induced Neuroinflammation in a Mouse Model of Breast Cancer
Gaudier-Diaz M, Lustberg M, Cole R, Belury M, DeVries A, Orchard T. Effects of Sucrose and Omega-3 Fatty Acids on Chemotherapy-Induced Neuroinflammation in a Mouse Model of Breast Cancer. Journal Of The Academy Of Nutrition And Dietetics 2015, 115: a25. DOI: 10.1016/j.jand.2015.06.081.Peer-Reviewed Original Research