2018
A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer
Borniger J, Walker W, Surbhi, Emmer K, Zhang N, Zalenski A, Muscarella S, Fitzgerald J, Smith A, Braam C, TinKai T, Magalang U, Lustberg M, Nelson R, DeVries A. A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer. Cell Metabolism 2018, 28: 118-129.e5. PMID: 29805100, PMCID: PMC6031468, DOI: 10.1016/j.cmet.2018.04.021.Peer-Reviewed Original ResearchConceptsTumor-bearing miceSleep abnormalitiesMetabolic abnormalitiesIL-6Non-metastatic breast cancerHypocretin/orexin neuronsHypothalamic hypocretin/orexin neuronsPeripheral sympathetic denervationSerum leptin concentrationsTumor-induced increaseTumor-induced changesEnhanced sleep qualityHypocretin/orexinPeripheral inflammationSympathetic denervationExogenous ghrelinOrexin neuronsLeptin concentrationsInterleukin-6Serum glucoseMammary cancerBreast cancerSleep qualityMouse modelCentral neuromodulators
2016
Breast cancer and social environment: getting by with a little help from our friends
Hinzey A, Gaudier-Diaz M, Lustberg M, DeVries A. Breast cancer and social environment: getting by with a little help from our friends. Breast Cancer Research 2016, 18: 54. PMID: 27225892, PMCID: PMC4881170, DOI: 10.1186/s13058-016-0700-x.Peer-Reviewed Original ResearchConceptsTumor growthBreast cancerBreast cancer survivorsBreast cancer patientsIdentification of patientsCancer-related mortalityMammary tumor growthBreast cancer progressionBasic science literatureInadequate social supportTherapeutic complementCancer survivorsPoor outcomeCancer patientsTumor progressionProtective pathwaysContemporary treatmentDetrimental pathwaysCancer progressionTargeted disruptionUnderlying physiological mechanismsSocial isolationPatientsCancerSocial support