2019
In vitro and in vivo activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2 (Trop-2) in uterine serous carcinoma
Han C, Perrone E, Zeybek B, Bellone S, Tymon-Rosario J, Altwerger G, Menderes G, Feinberg J, Haines K, Muller Karger ME, Bianchi A, Zammataro L, Manzano A, Bonazzoli E, Manara P, Buza N, Hui P, Ratner E, Silasi DA, Huang GS, Azodi M, Schwartz PE, Lopez S, Santin AD. In vitro and in vivo activity of sacituzumab govitecan, an antibody-drug conjugate targeting trophoblast cell-surface antigen 2 (Trop-2) in uterine serous carcinoma. Gynecologic Oncology 2019, 156: 430-438. PMID: 31839338, DOI: 10.1016/j.ygyno.2019.11.018.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, Monoclonal, HumanizedAntibody-Dependent Cell CytotoxicityAntigens, NeoplasmCamptothecinCell Adhesion MoleculesCell Line, TumorCystadenocarcinoma, SerousFemaleFlow CytometryHumansImmunoconjugatesImmunohistochemistryMiceMice, SCIDMolecular Targeted TherapyRandom AllocationTissue Array AnalysisUterine NeoplasmsXenograft Model Antitumor AssaysConceptsUterine serous carcinomaCell surface antigen 2Sacituzumab govitecanTrop-2 expressionTrop-2Serous carcinomaAntigen 2Advanced/recurrent diseasePrimary uterine serous carcinomaResistant human tumorsSignificant bystander killingUSC patientsUSC xenograftsRecurrent diseaseClinical responseEndometrial cancerAggressive variantPoor prognosisPreclinical activityPrimary tumorIntravenous administrationClinical developmentUSC samplesActive metaboliteSN-38
2017
Natural Orifice–Assisted Laparoscopic Meckel Diverticulectomy Incidentally Found During Para-Aortic Mass Resection
Menderes G, Dugan K, Klein MJ, Azodi M. Natural Orifice–Assisted Laparoscopic Meckel Diverticulectomy Incidentally Found During Para-Aortic Mass Resection. Journal Of Minimally Invasive Gynecology 2017, 25: 19-20. PMID: 28478192, DOI: 10.1016/j.jmig.2017.04.015.Peer-Reviewed Original ResearchConceptsPara-aortic massLeft para-aortic massStage IV choriocarcinomaMeckel's diverticulumRetroperitoneal schwannomaPosterior colpotomyLaparoscopic resectionLaparoscopic approachAbdominal incisionExcellent clinical responseForm of etoposideIncidental Meckel's diverticulumLaparoscopic Meckel's diverticulectomyPostoperative day 0Tertiary referral centerUneventful postoperative courseCompletion of surgeryPara-aortic areaAbdominal portsMeckel's diverticulectomyRetroperitoneal attachmentsMass resectionPostoperative courseClinical responseMetastatic disease