2014
Phase I Clinical Trial of the Mammalian Target of Rapamycin Inhibitor Everolimus in Combination With Oral Topotecan for Recurrent and Advanced Endometrial Cancer
Acevedo-Gadea C, Santin AD, Higgins SA, Urva S, Ratner E, Silasi DA, Azodi M, Rutherford T, Schwartz PE, Abu-Khalaf MM. Phase I Clinical Trial of the Mammalian Target of Rapamycin Inhibitor Everolimus in Combination With Oral Topotecan for Recurrent and Advanced Endometrial Cancer. International Journal Of Gynecological Cancer 2014, 24: 528-533. PMID: 24557436, DOI: 10.1097/igc.0000000000000085.Peer-Reviewed Original ResearchConceptsOral topotecanEndometrial cancerDay 1Pelvic external beam radiation therapyMammalian targetExternal beam radiation therapyPhase I clinical trialRecurrent endometrial cancerAdvanced endometrial cancerDose-limiting toxicityEfficacy of topotecanRapamycin inhibitor everolimusBeam radiation therapyOral everolimusStable diseaseVaginal brachytherapyMedian ageRapamycin inhibitorsInhibitor everolimusPreclinical dataClinical trialsMedian numberPharmacokinetic assessmentRadiation therapyEverolimus
2009
Brain Metastases in Epithelial Ovarian and Primary Peritoneal Carcinoma
Ratner ES, Toy E, O'Malley DM, Mcalpine J, Rutherford TJ, Azodi M, Higgins SA, Schwartz PE. Brain Metastases in Epithelial Ovarian and Primary Peritoneal Carcinoma. International Journal Of Gynecological Cancer 2009, 19: 856-859. PMID: 19574773, DOI: 10.1111/igc.0b013e3181a83301.Peer-Reviewed Original ResearchConceptsWhole-brain radiation therapyPrimary peritoneal cancerBrain metastatic diseaseEpithelial ovarian cancerGamma knife radiosurgeryBrain metastasesKnife radiosurgeryRadiation therapySingle lesionPostoperative whole-brain radiation therapyCentral nervous system metastasesLargest single-institution experienceNervous system metastasesPrimary peritoneal carcinomaShorter median timeSingle institution experienceMultiple brain lesionsLong-term survivalEpithelial ovarianMedian survivalPaclitaxel therapyPeritoneal cancerPeritoneal carcinomaMetastatic diseaseRetrospective review