2014
Flutamide and Biomarkers in Women at High Risk for Ovarian Cancer: Preclinical and Clinical Evidence
Gruessner C, Gruessner A, Glaser K, AbuShahin N, Zhou Y, Laughren C, Wright H, Pinkerton S, Yi X, Stoffer J, Azodi M, Zheng W, Chambers SK. Flutamide and Biomarkers in Women at High Risk for Ovarian Cancer: Preclinical and Clinical Evidence. Cancer Prevention Research 2014, 7: 896-905. PMID: 24950779, PMCID: PMC4154987, DOI: 10.1158/1940-6207.capr-13-0408.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogen AntagonistsAnimalsAntineoplastic Agents, HormonalArea Under CurveBiomarkers, TumorEnzyme-Linked Immunosorbent AssayFallopian Tube NeoplasmsFallopian TubesFemaleFlutamideGenetic Predisposition to DiseaseHumansImmunohistochemistryMacrophage Colony-Stimulating FactorMaleMiceMice, NudeMiddle AgedOvarian NeoplasmsOvariectomyOvaryReceptor, ErbB-4Risk FactorsROC CurveSalpingectomyConceptsOvarian endosalpingiosisOvarian stromaFlutamide treatmentOvarian cancerHigh riskBRCA carrier statusOvarian cancer initiationPhase II studyRole of androgensPelvic serous cancerEffect of flutamideOvarian cancer developmentCSF-1High predictive valueLogistic regression modelsAndrogen ablationII studySerous cancerTumor burdenClinical evidenceBRCA mutationsFallopian tubeCSF-1RMale miceAndrogen action
2004
Patients with uterine papillary serous cancers may benefit from adjuvant platinum-based chemoradiation
Kelly MG, O'Malley D, Hui P, McAlpine J, Dziura J, Rutherford TJ, Azodi M, Chambers SK, Schwartz PE. Patients with uterine papillary serous cancers may benefit from adjuvant platinum-based chemoradiation. Gynecologic Oncology 2004, 95: 469-473. PMID: 15581948, DOI: 10.1016/j.ygyno.2004.08.030.Peer-Reviewed Original ResearchConceptsUterine papillary serous carcinomaStage IA patientsResidual uterine diseaseAdvanced stage uterine papillary serous carcinomaIA patientsUterine diseaseSerous cancerUterine papillary serous cancerComplete surgical stagingObstetrics stage IAPapillary serous cancerDifferent therapeutic optionsPapillary serous carcinomaPlatinum-based chemoradiationMore effective treatmentsLocoregional diseaseHysterectomy specimenStage IAStage IIIAStage IIICSurgical stagingExtrauterine metastasesSerous carcinomaTherapeutic optionsFallopian tube