2019
Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial
Moore KN, Secord AA, Geller MA, Miller DS, Cloven N, Fleming GF, Wahner Hendrickson AE, Azodi M, DiSilvestro P, Oza AM, Cristea M, Berek JS, Chan JK, Rimel BJ, Matei DE, Li Y, Sun K, Luptakova K, Matulonis UA, Monk BJ. Niraparib monotherapy for late-line treatment of ovarian cancer (QUADRA): a multicentre, open-label, single-arm, phase 2 trial. The Lancet Oncology 2019, 20: 636-648. PMID: 30948273, DOI: 10.1016/s1470-2045(19)30029-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBRCA1 ProteinBRCA2 ProteinCanadaCarcinoma, Ovarian EpithelialFallopian Tube NeoplasmsFemaleHumansIndazolesMiddle AgedMutationOvarian NeoplasmsPeritoneal NeoplasmsPiperidinesPoly(ADP-ribose) Polymerase InhibitorsProgression-Free SurvivalTime FactorsUnited StatesYoung AdultConceptsProportion of patientsOvarian cancerAdverse eventsOverall survivalBRCA mutationsCommon treatment-emergent serious adverse eventsCommon drug-related grade 3Treatment-emergent serious adverse eventsWorse treatment-emergent adverse eventsDrug-related grade 3Last platinum-based therapyLater-line treatment optionTreatment-emergent adverse eventsLater-line treatmentPrevious chemotherapy regimensPrimary efficacy populationMedian overall survivalPlatinum-sensitive diseasePrimary peritoneal cancerSerious adverse eventsThird-line therapyLines of therapyNew safety signalsPhase 2 studyPhase 2 trial
2012
Vaginal Cuff Dehiscence in Robotic-Assisted Total Hysterectomy
Kashani S, Gallo T, Sargent A, ElSahwi K, Silasi DA, Azodi M. Vaginal Cuff Dehiscence in Robotic-Assisted Total Hysterectomy. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 2012, 16: 530-536. PMID: 23484559, PMCID: PMC3558887, DOI: 10.4293/108680812x13462882736817.Peer-Reviewed Original ResearchConceptsRobotic-assisted total laparoscopic hysterectomyVaginal cuff dehiscenceTotal laparoscopic hysterectomyRobotic-assisted total hysterectomyCuff dehiscenceLaparoscopic hysterectomyTotal hysterectomyCumulative incidenceDehiscence rateCanadian Task Force Classification IIVaginal cuff suturingObservational case seriesCommunity teaching hospitalDa Vinci Surgical SystemVinci Surgical SystemVaginal hysterectomyCase seriesSingle surgeonPatient educationTeaching hospitalBenign reasonsHysterectomyClassification IIDehiscenceIncidence