2014
Flutamide and Biomarkers in Women at High Risk for Ovarian Cancer: Preclinical and Clinical Evidence
Gruessner C, Gruessner A, Glaser K, AbuShahin N, Zhou Y, Laughren C, Wright H, Pinkerton S, Yi X, Stoffer J, Azodi M, Zheng W, Chambers SK. Flutamide and Biomarkers in Women at High Risk for Ovarian Cancer: Preclinical and Clinical Evidence. Cancer Prevention Research 2014, 7: 896-905. PMID: 24950779, PMCID: PMC4154987, DOI: 10.1158/1940-6207.capr-13-0408.Peer-Reviewed Original ResearchMeSH KeywordsAdultAndrogen AntagonistsAnimalsAntineoplastic Agents, HormonalArea Under CurveBiomarkers, TumorEnzyme-Linked Immunosorbent AssayFallopian Tube NeoplasmsFallopian TubesFemaleFlutamideGenetic Predisposition to DiseaseHumansImmunohistochemistryMacrophage Colony-Stimulating FactorMaleMiceMice, NudeMiddle AgedOvarian NeoplasmsOvariectomyOvaryReceptor, ErbB-4Risk FactorsROC CurveSalpingectomyConceptsOvarian endosalpingiosisOvarian stromaFlutamide treatmentOvarian cancerHigh riskBRCA carrier statusOvarian cancer initiationPhase II studyRole of androgensPelvic serous cancerEffect of flutamideOvarian cancer developmentCSF-1High predictive valueLogistic regression modelsAndrogen ablationII studySerous cancerTumor burdenClinical evidenceBRCA mutationsFallopian tubeCSF-1RMale miceAndrogen action
2010
Inhibition of the c-fms proto-oncogene autocrine loop and tumor phenotype in glucocorticoid stimulated human breast carcinoma cells
Toy EP, Lamb T, Azodi M, Roy WJ, Woo HH, Chambers SK. Inhibition of the c-fms proto-oncogene autocrine loop and tumor phenotype in glucocorticoid stimulated human breast carcinoma cells. Breast Cancer Research And Treatment 2010, 129: 411-419. PMID: 21063905, DOI: 10.1007/s10549-010-1247-7.Peer-Reviewed Original ResearchMeSH KeywordsAutocrine CommunicationBreast NeoplasmsCarcinomaCell AdhesionCell Line, TumorCell MovementDexamethasoneDose-Response Relationship, DrugFemaleGlucocorticoidsHumansMacrophage Colony-Stimulating FactorNeoplasm InvasivenessOligonucleotides, AntisensePhenotypePhenylurea CompoundsProtein Kinase InhibitorsProto-Oncogene MasReceptor, Macrophage Colony-Stimulating FactorRNA InterferenceThiazolesTransfectionConceptsC-fms signalingBreast cancer cellsAntisense oligonucleotide therapyBreast cancerGC stimulationC-fms expressionCancer cellsBreast cancer cell invasionTargeted molecular therapiesHuman breast cancer cellsCo-expressed receptorsAutocrine feedback loopDose-response mannerC-fms mRNAHuman breast carcinoma cellsBreast tumor behaviorReceptor/ligand pairsBreast carcinoma cellsCancer cell invasionInhibition of glucocorticoidsC-fmsAutocrine pathwayClinical utilityParacrine mannerTumor behavior
2009
Enhanced Ovarian Cancer Tumorigenesis and Metastasis by the Macrophage Colony-Stimulating Factor
Toy EP, Azodi M, Folk NL, Zito CM, Zeiss CJ, Chambers SK. Enhanced Ovarian Cancer Tumorigenesis and Metastasis by the Macrophage Colony-Stimulating Factor. Neoplasia 2009, 11: 136-144. PMID: 19177198, PMCID: PMC2631138, DOI: 10.1593/neo.81150.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkers, TumorCell AdhesionCell MovementCell Transformation, NeoplasticFemaleHumansMacrophage Colony-Stimulating FactorMiceMice, NudeNeoplasm InvasivenessNeoplasm MetastasisNeoplasm TransplantationNeoplasms, ExperimentalOligonucleotides, AntisenseOvarian NeoplasmsPhenotypeReceptor, Macrophage Colony-Stimulating FactorTumor Cells, Cultured
2005
Glyceraldehyde-3-Phosphate Dehydrogenase Binds to the AU-Rich 3′ Untranslated Region of Colony-Stimulating Factor–1 (CSF-1) Messenger RNA in Human Ovarian Cancer Cells: Possible Role in CSF-1 Posttranscriptional Regulation and Tumor Phenotype
Bonafé N, Gilmore-Hebert M, Folk NL, Azodi M, Zhou Y, Chambers SK. Glyceraldehyde-3-Phosphate Dehydrogenase Binds to the AU-Rich 3′ Untranslated Region of Colony-Stimulating Factor–1 (CSF-1) Messenger RNA in Human Ovarian Cancer Cells: Possible Role in CSF-1 Posttranscriptional Regulation and Tumor Phenotype. Cancer Research 2005, 65: 3762-3771. PMID: 15867372, DOI: 10.1158/0008-5472.can-04-3954.Peer-Reviewed Original ResearchConceptsHEY cellsOvarian cancer cellsCancer cellsMalignant ovarian epithelial cellsMetastatic propertiesEpithelial ovarian cancer cellsHuman ovarian cancer cellsCSF-1Ovarian epithelial cellsColony-stimulating factorPoor prognosisOvarian cancerCSF-1 expressionTumor phenotypeSuch cancer cellsEpithelial cellsUrokinase activityGlyceraldehyde-3-phosphate dehydrogenaseAberrant abundanceCell linesPossible roleProtein translation