2013
Characterization of the adipocyte cellular lineage in vivo
Berry R, Rodeheffer MS. Characterization of the adipocyte cellular lineage in vivo. Nature Cell Biology 2013, 15: 302-308. PMID: 23434825, PMCID: PMC3721064, DOI: 10.1038/ncb2696.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytes, WhiteAdipogenesisAnimalsAntigens, CDBlotting, WesternCadherinsCell DifferentiationCell LineageCell ProliferationEndothelium, VascularFlow CytometryHematopoietic Stem CellsMaleMiceMice, Inbred C57BLMice, TransgenicReal-Time Polymerase Chain ReactionReceptor, Platelet-Derived Growth Factor alphaReverse Transcriptase Polymerase Chain ReactionRNA, Messenger
2011
Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis
Birsoy K, Berry R, Wang T, Ceyhan O, Tavazoie S, Friedman JM, Rodeheffer MS. Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis. Development 2011, 138: 4709-4719. PMID: 21989915, PMCID: PMC3190384, DOI: 10.1242/dev.067710.Peer-Reviewed Original ResearchMeSH Keywords3T3-L1 CellsAdipogenesisAdipose Tissue, WhiteAnimalsGene Expression Regulation, DevelopmentalGene Knockdown TechniquesGene Regulatory NetworksHumansMaleMiceMice, Inbred C57BLMice, TransgenicMicroarray AnalysisNF-E2-Related Factor 2Promoter Regions, GeneticProto-Oncogene Protein c-ets-1Proto-Oncogene Protein c-ets-2ConceptsTranscription factorsWhite adipose tissue developmentGene networksAdipose tissue developmentGene expressionTissue developmentETS transcription factorsEarly gene clusterDistinct transcriptional programsWAT developmentAdipocyte differentiation programImportant transcription factorFormation of adipocytesMotif discovery toolsGene clusterEarly adipogenesisTranscriptional programsDifferentiation programBAC transgenic miceDNA microarraysDevelopmental transitionsMolecular mechanismsMolecular characterizationSignificant enrichmentEts2
2008
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer MS, Birsoy K, Friedman JM. Identification of White Adipocyte Progenitor Cells In Vivo. Cell 2008, 135: 240-249. PMID: 18835024, DOI: 10.1016/j.cell.2008.09.036.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytes, WhiteAdipogenesisAnimalsCell ProliferationFemaleFlow CytometryLipodystrophyMiceMice, TransgenicObesityStem CellsConceptsAdipocyte progenitor cellsWhite adipocyte progenitor cellsWhite adipose tissue massProgenitor cellsAdipose tissue massHypertrophy of adipocytesAdipose tissue stromaLipodystrophic miceWAT depotsDiabetic phenotypeAdipocyte numberAdipose depotsCells residentTissue massFat padTissue stromaNoninvasive assayVivoCellsReportObesityHyperplasiaDepotsHypertrophyMice