2024
Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications
Talcott W, Marta G, Moran M. Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications. Advances In Radiation Oncology 2024, 9: 101569. PMID: 39188995, PMCID: PMC11345291, DOI: 10.1016/j.adro.2024.101569.Peer-Reviewed Original ResearchPost-operative radiationNipple-sparing mastectomyRegional nodal irradiationAdverse pathologic featuresOverall survivalPathological featuresEarly-stage breast cancerNational Cancer DatabasePost-operative settingType of surgeryHigh-risk subgroupsNipple preservationNodal irradiationPN+ ratePositive marginsRadiation deliveryInvasive carcinomaSurgical subtypesCancer DatabaseLymph nodesPatient selectionPN+Breast cancerCox regressionMultivariate analysis
2023
Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Small W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA. Journal Of Clinical Oncology 2023, 42: 390-398. PMID: 38060195, DOI: 10.1200/jco.23.02270.Peer-Reviewed Original ResearchBreast-conserving surgeryIpsilateral breast eventsEndocrine therapyPostmenopausal patientsBreast cancerCrude rateLower riskBreast cancer-specific survival ratesUnifocal invasive breast cancersYears of ETCancer-specific survival ratesStage I breast cancerHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Omission of radiotherapyYounger postmenopausal patientsPatients age 50Primary end pointBreast conserving surgeryGrowth factor receptor 2I breast cancerInvasive breast cancerRecurrence 5 yearsPatients age 65Single-arm trial
2022
Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None?
Moran M, Ho A. Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None? Journal Of Clinical Oncology 2022, 40: 4166-4172. PMID: 36332170, DOI: 10.1200/jco.22.01751.Peer-Reviewed Original ResearchConceptsWide local excisionPartial breast irradiationBreast cancerRadiation therapyEstrogen receptor-positive/progesteroneLow-risk breast cancerOncology Grand Rounds seriesHuman epidermal growth factor receptor 2Left-sided breast cancerWhole breast radiation therapyEpidermal growth factor receptor 2Clinical-pathologic featuresPostmenopausal female patientsDose/fractionationGrowth factor receptor 2Sentinel node biopsyOmission of radiationCommon clinical scenariosFactor receptor 2Node biopsyPostoperative radiationLocal excisionFemale patientsBreast irradiationTreatment recommendations
2021
CLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated
Peters G, Gao S, Knowlton C, Zhang A, Evans S, Higgins S, Wilson L, Saltmarsh N, Picone M, Moran M. CLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated. Journal Of The National Comprehensive Cancer Network 2021, 19: clo21-025. DOI: 10.6004/jnccn.2020.7707.Peer-Reviewed Original Research
2019
Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Thomas T, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: s7-s8. DOI: 10.1016/j.ijrobp.2019.06.392.Peer-Reviewed Original ResearchPV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB
Chowdhary M, Lee A, Gao S, Barry P, Diaz R, Bagadiya N, Park H, Yu J, Wilson L, Moran M, Higgins S, Knowlton C, Patel K. PV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB. Radiotherapy And Oncology 2019, 133: s15. DOI: 10.1016/s0167-8140(19)30465-7.Peer-Reviewed Original Research
2017
Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer
Moran M. Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer. 2017, 151-170. DOI: 10.1007/978-3-319-59198-8_9.Peer-Reviewed Original ResearchBreast cancerMutation carriersRadiation therapyLocal-regional managementPost-mastectomy settingBreast conservation therapyBRCA mutation carriersTreatment management decisionsBRCA mutation statusHereditary breast cancerBreast conservationTNBC patientsConservation therapyBRCA carriersFamily historyMutation statusRadiation therapy deliveryTreatment conceptGenetic testingBRCA genesCancerTherapyStrong associationTherapy deliveryPresent guidelines
2016
Radiosensitization effect of Huaier on breast cancer cells
DING X, YANG Q, KONG X, HAFFTY BG, GAO S, MORAN MS. Radiosensitization effect of Huaier on breast cancer cells. Oncology Reports 2016, 35: 2843-2850. PMID: 26935024, DOI: 10.3892/or.2016.4630.Peer-Reviewed Original ResearchConceptsBreast cancer cellsDNA repairTraditional Chinese medicineCell cycleBreast cancerCancer cellsDNA repair pathwaysCell cycle-regulating proteinsHomologous recombination pathwayRadiosensitization effectMulti-biological functionsCell cycle phasesColony formation assaysMDA-MB-468 cellsΓ-H2AX fociCell divisionRepair pathwaysG0/G1Treatment strategiesMicroarray assayRecombination pathwayFormation assaysHuaierCancer treatmentWestern blottingRecent Updates in the Management of Triple Negative Breast Cancer
Sanft T, Moran M. Recent Updates in the Management of Triple Negative Breast Cancer. TouchREVIEWS In Oncology & Haematology 2016, 12: 36. DOI: 10.17925/ohr.2016.12.01.36.Peer-Reviewed Original ResearchTriple-negative breast cancerNegative breast cancerBreast cancerLocoregional treatment optionsComplete pathologic responseNeoadjuvant chemotherapyPathologic responseResidual diseaseTreatment optionsAggressive subtypeNew agentsCancerDruggable targetsDisease biologyRecent updatesFurther researchChemotherapyPatientsTherapySubtypesDisease
2015
Assessment of Practice Patterns Following Publication of the SSO–ASTRO Consensus Guideline on Margins for Breast-Conserving Therapy in Stage I and II Invasive Breast Cancer
DeSnyder SM, Hunt KK, Smith BD, Moran MS, Klimberg S, Lucci A. Assessment of Practice Patterns Following Publication of the SSO–ASTRO Consensus Guideline on Margins for Breast-Conserving Therapy in Stage I and II Invasive Breast Cancer. Annals Of Surgical Oncology 2015, 22: 3250-3256. PMID: 26202554, PMCID: PMC4696114, DOI: 10.1245/s10434-015-4666-1.Peer-Reviewed Original ResearchConceptsConsensus guidelinesInked marginInvasive breast cancerBreast-Conserving TherapyTriple-negative tumorsCurrent clinical practiceIndividual clinical judgmentDuctal carcinomaBreast surgeonsPractice patternsBreast cancerStage IClinical practiceClinical judgmentTumorsMethodsA surveyAdequate marginsPractice typeMultiple fociAmerican SocietySurgeonsGuidelinesMultiple marginsCarcinomaTherapyRadiation therapy in the locoregional treatment of triple-negative breast cancer
Moran MS. Radiation therapy in the locoregional treatment of triple-negative breast cancer. The Lancet Oncology 2015, 16: e113-e122. PMID: 25752562, DOI: 10.1016/s1470-2045(14)71104-0.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorDecision Support TechniquesDose Fractionation, RadiationFemaleGenetic Predisposition to DiseaseHumansMastectomyNeoplasm Recurrence, LocalPatient SelectionPhenotypePredictive Value of TestsRadiation ToleranceRadiotherapy, AdjuvantRisk AssessmentRisk FactorsTreatment OutcomeTriple Negative Breast Neoplasms
2014
Nomogram for Predicting the Risk of Locoregional Recurrence in Patients Treated With Accelerated Partial-Breast Irradiation
Wobb JL, Chen PY, Shah C, Moran MS, Shaitelman SF, Vicini FA, Mbah AK, Lyden M, Beitsch P. Nomogram for Predicting the Risk of Locoregional Recurrence in Patients Treated With Accelerated Partial-Breast Irradiation. International Journal Of Radiation Oncology • Biology • Physics 2014, 91: 312-318. PMID: 25446607, DOI: 10.1016/j.ijrobp.2014.09.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsBrachytherapyBreast NeoplasmsDose Fractionation, RadiationFemaleHumansMiddle AgedNeoplasm Recurrence, LocalNomogramsOrgan Sparing TreatmentsOutcome Assessment, Health CarePrognosisReproducibility of ResultsRisk AssessmentSensitivity and SpecificityUnited StatesConceptsLocoregional recurrencePartial breast irradiationConcordance indexBreast Surgeons MammoSite Registry TrialCox proportional hazards regression modelRisk of LRREarly-stage breast cancerProportional hazards regression modelsAccelerated Partial Breast IrradiationEstrogen receptor negativityBalloon-based brachytherapyHazards regression modelsWilliam Beaumont HospitalConformal radiation therapyBias-corrected indicesReceptor negativityRegistry trialClinicopathologic featuresPositive marginsClinicopathologic variablesBeaumont HospitalUnivariate analysisBreast cancerUse nomogramRadiation therapyNomogram for predicting the risk of locoregional recurrence in patients treated with accelerated partial-breast irradiation.
Wobb J, Chen P, Shah C, Moran M, Shaitelman S, Vicini F, Mbah A, Lyden M, Beitsch P. Nomogram for predicting the risk of locoregional recurrence in patients treated with accelerated partial-breast irradiation. Journal Of Clinical Oncology 2014, 32: 59-59. DOI: 10.1200/jco.2014.32.26_suppl.59.Peer-Reviewed Original ResearchLocoregional recurrenceC-indexCox proportional hazards regression modelRisk of LRREarly-stage breast cancerProportional hazards regression modelsStage breast cancerBalloon-based brachytherapyHazards regression modelsWilliam Beaumont HospitalPartial breast irradiationBias-corrected indicesRegistry trialClinicopathologic featuresER negativityPositive marginsClinicopathologic variablesBeaumont HospitalPerimenopausal statusUnivariate analysisBreast cancerUse nomogramConformal radiotherapyPatientsAPBISignificance of Phospho(Ser73)-K8 Expression in Women With Breast Cancer of Triple Negative Phenotype
Garg R, Housri N, Kongara S, Wu H, Schiff D, Moran M, Karantza V, Haffty B. Significance of Phospho(Ser73)-K8 Expression in Women With Breast Cancer of Triple Negative Phenotype. International Journal Of Radiation Oncology • Biology • Physics 2014, 90: s69-s70. DOI: 10.1016/j.ijrobp.2014.05.230.Peer-Reviewed Original ResearchThe Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer: Perspectives for Pathologists
Schnitt SJ, Moran MS, Houssami N, Morrow M. The Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer: Perspectives for Pathologists. Archives Of Pathology & Laboratory Medicine 2014, 139: 575-7. PMID: 25153620, DOI: 10.5858/arpa.2014-0384-ed.Peer-Reviewed Original ResearchShould triple-negative breast cancer (TNBC) subtype affect local-regional therapy decision making?
Moran MS. Should triple-negative breast cancer (TNBC) subtype affect local-regional therapy decision making? American Society Of Clinical Oncology Educational Book 2014, e32-6. PMID: 24857120, DOI: 10.14694/edbook_am.2014.34.e32.Peer-Reviewed Original ResearchConceptsTriple-negative breast cancerLocal-regional relapseBreast cancer therapySporadic triple-negative breast cancerBreast cancerEarly-stage triple-negative breast cancerYounger ageAggressive biologic characteristicsBreast conservation approachHER2-positive subgroupContralateral breast cancerWhole breast irradiationDefinitive treatment strategyNegative breast cancer subtypeHypothesis-generating dataPartial breast irradiationBreast cancer subtypesBRCA1 mutation carriersSystemic chemotherapyAdvanced diseaseRandomized trialsGuideline recommendationsLuminal tumorsBreast irradiationTNBC subtypesSociety of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer
Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M. Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer. Annals Of Surgical Oncology 2014, 21: 704-716. PMID: 24515565, DOI: 10.1245/s10434-014-3481-4.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceInvasive breast cancerBreast cancerClear marginsRate of IBTRRisk of IBTRRadiation Oncology consensus guidelinesSurgical Oncology–American SocietyMargin widthMultidisciplinary consensus panelOptimal margin widthBreast tumor recurrenceExtensive intraductal componentBreast conserving surgeryBreast-conserving surgeryRe-excision ratesHealth care costsUnfavorable biologyEndocrine therapyMultidisciplinary therapyRadiation boostYounger patientsIntraductal componentLobular cancerNegative marginsACR Appropriateness Criteria local-regional recurrence (LRR) and salvage surgery-breast cancer.
Halyard MY, Harris EE, Bailey L, Bellon JR, Freedman GM, Goyal S, Horst KC, Moran MS, Park CC, Suh WW, Toppmeyer D, Haffty BG. ACR Appropriateness Criteria local-regional recurrence (LRR) and salvage surgery-breast cancer. Oncology 2014, 28: 157-64, c3. PMID: 24701707.Peer-Reviewed Original ResearchConceptsLocal-regional recurrenceAmerican CollegeRadiology Appropriateness Criteria Expert PanelExcellent local-regional controlAppropriateness of imagingLocal-regional controlTreatment-related factorsBreast-conserving surgeryExpert panelMultidisciplinary expert panelRadiology Appropriateness CriteriaEvidence-based guidelinesSpecific clinical conditionsCurrent medical literatureEvidence-based dataHormonal therapyAppropriateness CriteriaBreast cancerClinical conditionsExpert opinionGuideline developmentClinical scenariosAvailable modalitiesMedical literaturePatient scenarios
2013
The Relative Benefits of Tamoxifen in Older Women with T1 Early‐Stage Breast Cancer Treated with Breast‐Conserving Surgery and Radiation Therapy
Khan AJ, Parikh RR, Neboori HJ, Goyal S, Haffty BG, Moran MS. The Relative Benefits of Tamoxifen in Older Women with T1 Early‐Stage Breast Cancer Treated with Breast‐Conserving Surgery and Radiation Therapy. The Breast Journal 2013, 19: 490-495. PMID: 23800027, DOI: 10.1111/tbj.12150.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalLocal relapse-free survivalUse of tamoxifenOverall survivalBreast relapseBreast cancerRadiation therapyOlder womenHormone receptor-positive breast carcinomaElderly breast cancer patientsNode-negative breast cancerEarly-stage breast cancerLow local recurrence rateInstitutional data baseIpsilateral breast relapseT1N0M0 breast cancerAdjuvant hormonal therapyAdjuvant radiation therapyBreast conserving surgeryContralateral breast cancerLocal recurrence rateBreast-conserving surgeryMetastasis-free survivalRelapse-free survivalBreast cancer patients
2012
Association Between Tumor Molecular Subtype and Disease Presentation in Patients With Early-stage Breast Cancer
Jones T, Neboori H, Haffty B, Wu H, Yang Q, Moran M. Association Between Tumor Molecular Subtype and Disease Presentation in Patients With Early-stage Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: s141. DOI: 10.1016/j.ijrobp.2012.07.164.Peer-Reviewed Original Research