2022
Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None?
Moran M, Ho A. Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None? Journal Of Clinical Oncology 2022, 40: 4166-4172. PMID: 36332170, DOI: 10.1200/jco.22.01751.Peer-Reviewed Original ResearchConceptsWide local excisionPartial breast irradiationBreast cancerRadiation therapyEstrogen receptor-positive/progesteroneLow-risk breast cancerOncology Grand Rounds seriesHuman epidermal growth factor receptor 2Left-sided breast cancerWhole breast radiation therapyEpidermal growth factor receptor 2Clinical-pathologic featuresPostmenopausal female patientsDose/fractionationGrowth factor receptor 2Sentinel node biopsyOmission of radiationCommon clinical scenariosFactor receptor 2Node biopsyPostoperative radiationLocal excisionFemale patientsBreast irradiationTreatment recommendations
2011
Breast Conservation Therapy for Ductal Carcinoma In Situ (DCIS): Is there a difference in Clinical-Pathologic Features and Long Term Outcomes in Occult, Mammographically-Detected Disease Compared with DCIS Presenting with Physical Findings?
Bai H, Lannin D, Higgins S, Motwani S, Hafty B, Goyal S, Wilson L, Evans S, Moran M. Breast Conservation Therapy for Ductal Carcinoma In Situ (DCIS): Is there a difference in Clinical-Pathologic Features and Long Term Outcomes in Occult, Mammographically-Detected Disease Compared with DCIS Presenting with Physical Findings? International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s245. DOI: 10.1016/j.ijrobp.2011.06.1716.Peer-Reviewed Original ResearchBreast cancers in U.S. residing Indian-Pakistani versus non-Hispanic White women: comparative analysis of clinical-pathologic features, treatment, and survival
Moran MS, Gonsalves L, Goss DM, Ma S. Breast cancers in U.S. residing Indian-Pakistani versus non-Hispanic White women: comparative analysis of clinical-pathologic features, treatment, and survival. Breast Cancer Research And Treatment 2011, 128: 543-551. PMID: 21301957, PMCID: PMC3235412, DOI: 10.1007/s10549-011-1362-0.Peer-Reviewed Original ResearchConceptsBreast conservation surgeryAge-adjusted incidenceBreast cancerAdjuvant radiationNHW womenInvasive diseaseHormone receptor-negative diseaseFemale breast cancer patientsNon-Hispanic white womenPost-mastectomy RTRates of breastClinical-pathologic featuresInvolved lymph nodesPercentage of patientsReceptor-negative diseasePost-mastectomy radiationBreast cancer mortalityBreast cancer patientsLarger tumor sizeYounger median ageRelative survival ratesSignificant differencesMultivariate regression analysisSEER databaseLymph nodes
2010
Ductal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation
Parikh RR, Haffty BG, Lannin D, Moran MS. Ductal Carcinoma In Situ With Microinvasion: Prognostic Implications, Long-Term Outcomes, and Role of Axillary Evaluation. International Journal Of Radiation Oncology • Biology • Physics 2010, 82: 7-13. PMID: 20950955, DOI: 10.1016/j.ijrobp.2010.08.027.Peer-Reviewed Original ResearchConceptsDistant relapse-free survivalLocal-regional relapseClinical-pathologic featuresRelapse-free survivalBreast conservation therapyLong-term outcomesOverall survivalAxillary evaluationAxillary metastasesIndependent predictorsDuctal carcinomaCox proportional hazards analysisPresence of microinvasionSurgical axillary evaluationAdjuvant hormonal therapyProportional hazards analysisHormonal therapyAggressive treatmentDistant failureMargin statusSurgical evaluationConservation therapyPrognostic implicationsMean ageUnivariate analysis
2009
The Yale University Experience of Early‐Stage Invasive Lobular Carcinoma (ILC) and Invasive Ductal Carcinoma (IDC) Treated with Breast Conservation Treatment (BCT): Analysis of Clinical‐Pathologic Features, Long‐Term Outcomes, and Molecular Expression of COX‐2, Bcl‐2, and p53 as a Function of Histology
Moran MS, Yang Q, Haffty BG. The Yale University Experience of Early‐Stage Invasive Lobular Carcinoma (ILC) and Invasive Ductal Carcinoma (IDC) Treated with Breast Conservation Treatment (BCT): Analysis of Clinical‐Pathologic Features, Long‐Term Outcomes, and Molecular Expression of COX‐2, Bcl‐2, and p53 as a Function of Histology. The Breast Journal 2009, 15: 571-578. PMID: 19995377, DOI: 10.1111/j.1524-4741.2009.00833.x.Peer-Reviewed Original ResearchConceptsBreast conservation treatmentInvasive lobular carcinomaInvasive ductal carcinomaEarly-stage invasive lobular carcinomaClinical-pathologic featuresContralateral breast cancerCOX-2Breast relapseILC patientsDuctal carcinomaBreast cancerER/PR/HERBcl-2Cause-specific survivalLong-term outcomesTriple-negative tumorsChemo-preventive strategiesYears of ageImmuno-histochemical analysisExpression of p53Function of histologyDistant relapseInvasive lobularNodal statusContralateral breastClinical-Pathologic Features and Long-Term Outcomes of Tubular Carcinoma of the Breast Compared With Invasive Ductal Carcinoma Treated With Breast Conservation Therapy
Liu GF, Yang Q, Haffty BG, Moran MS. Clinical-Pathologic Features and Long-Term Outcomes of Tubular Carcinoma of the Breast Compared With Invasive Ductal Carcinoma Treated With Breast Conservation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 75: 1304-1308. PMID: 19386432, DOI: 10.1016/j.ijrobp.2008.12.070.Peer-Reviewed Original ResearchConceptsClinical-pathologic featuresInvasive ductal carcinomaRelapse-free survivalBreast conservation therapyLong-term outcomesConservation therapyTC cohortTumor RegistryDuctal carcinomaTubular carcinomaInstitutional experienceBreast cancer-related deathsNodal relapse-free survivalInstitution's tumor registryCentral pathology reviewHormone receptor positivityCancer-related deathPT1 diseaseConservative surgeryPN0 diseasePathology reviewClinical outcomesDistant metastasisRare subtypeRadiation therapy