2023
Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Small W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA. Journal Of Clinical Oncology 2023, 42: 390-398. PMID: 38060195, DOI: 10.1200/jco.23.02270.Peer-Reviewed Original ResearchBreast-conserving surgeryIpsilateral breast eventsEndocrine therapyPostmenopausal patientsBreast cancerCrude rateLower riskBreast cancer-specific survival ratesUnifocal invasive breast cancersYears of ETCancer-specific survival ratesStage I breast cancerHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Omission of radiotherapyYounger postmenopausal patientsPatients age 50Primary end pointBreast conserving surgeryGrowth factor receptor 2I breast cancerInvasive breast cancerRecurrence 5 yearsPatients age 65Single-arm trialPatient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction
Wong J, Uno H, Tramontano A, Pellegrini C, Bellon J, Cheney M, Hardenbergh P, Ho A, Horst K, Kim J, Leonard K, Moran M, Park C, Recht A, Shiloh R, Taghian A, Warren L, Wright J, Chun Y, Punglia R. Patient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e3-e4. DOI: 10.1016/j.ijrobp.2023.08.029.Peer-Reviewed Original ResearchPreoperative endocrine therapyCW toxicityEndocrine therapyQuality-of-lifeLymph nodesHF-PMRTRadiation therapyBreast reconstructionRandomized trialsResults Median follow-upChest wallTissue expanderImplant-based breast reconstructionImmediate prosthetic reconstructionPostmastectomy radiation therapyCompare quality-of-lifeMedian follow-upImplant-based reconstructionPost-operative infectionPlacement of tissue expandersMulticenter randomized trialQuality-of-life scoresSide effects of treatmentStage 0-III breast cancerPhysical well-being scores
2019
Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Thomas T, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: s7-s8. DOI: 10.1016/j.ijrobp.2019.06.392.Peer-Reviewed Original Research
2014
Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer
Moran MS, Schnitt SJ, Giuliano AE, Harris JR, Khan SA, Horton J, Klimberg S, Chavez-MacGregor M, Freedman G, Houssami N, Johnson PL, Morrow M. Society of Surgical Oncology–American Society for Radiation Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Stages I and II Invasive Breast Cancer. Annals Of Surgical Oncology 2014, 21: 704-716. PMID: 24515565, DOI: 10.1245/s10434-014-3481-4.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceInvasive breast cancerBreast cancerClear marginsRate of IBTRRisk of IBTRRadiation Oncology consensus guidelinesSurgical Oncology–American SocietyMargin widthMultidisciplinary consensus panelOptimal margin widthBreast tumor recurrenceExtensive intraductal componentBreast conserving surgeryBreast-conserving surgeryRe-excision ratesHealth care costsUnfavorable biologyEndocrine therapyMultidisciplinary therapyRadiation boostYounger patientsIntraductal componentLobular cancerNegative margins