2008
Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy
Yang Q, Moran MS, Haffty BG. Bcl-2 expression predicts local relapse for early-stage breast cancer receiving conserving surgery and radiotherapy. Breast Cancer Research And Treatment 2008, 115: 343. PMID: 18516673, DOI: 10.1007/s10549-008-0068-4.Peer-Reviewed Original ResearchConceptsEarly-stage breast cancerBreast conservation treatmentStage breast cancerBcl-2 expressionBreast cancerIpsilateral breast tumor recurrenceCox proportional hazards modelBreast tumor recurrenceIndependent prognostic factorProgesterone receptor statusOptimal treatment optionsBcl-2Proportional hazards modelBcl-2 antibodyApoptosis-related proteinsBreast recurrenceLocal relapseLocal recurrencePrognostic factorsReceptor statusClinical outcomesPrognostic significanceTreatment optionsTumor recurrencePrimary tumor
2006
SU‐FF‐T‐361: Planning Study of Intensity‐Modulated and 3D Conformal Radiotherapy of Whole Pelvis Including Inguinal Lymphatics: Radiobiological Considerations for Designing New Fractionation Schemes
Ahmad M, Song H, Lund M, Niemierko A, Moran M, Weidhaas J, Higgins S, Chen Z, Deng J, Nath R. SU‐FF‐T‐361: Planning Study of Intensity‐Modulated and 3D Conformal Radiotherapy of Whole Pelvis Including Inguinal Lymphatics: Radiobiological Considerations for Designing New Fractionation Schemes. Medical Physics 2006, 33: 2129-2129. DOI: 10.1118/1.2241281.Peer-Reviewed Original ResearchNormal tissue complication probabilityNode irradiationTumor control probabilityEquivalent uniform doseSIB-IMRTBoost plansTarget volumeNormal tissuesSimultaneous integrated boostShorter treatment durationIntensity-modulated radiotherapyPotential clinical advantagesAnal cancerSuperior dose distributionDose distributionDose escalationPrimary diseasePelvic malignanciesAdvanced tumorsWhole pelvisPrimary tumorSubclinical diseaseImproved outcomesIntegrated boostConformal radiotherapy