2023
Patient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction
Wong J, Uno H, Tramontano A, Pellegrini C, Bellon J, Cheney M, Hardenbergh P, Ho A, Horst K, Kim J, Leonard K, Moran M, Park C, Recht A, Shiloh R, Taghian A, Warren L, Wright J, Chun Y, Punglia R. Patient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e3-e4. DOI: 10.1016/j.ijrobp.2023.08.029.Peer-Reviewed Original ResearchPreoperative endocrine therapyCW toxicityEndocrine therapyQuality-of-lifeLymph nodesHF-PMRTRadiation therapyBreast reconstructionRandomized trialsResults Median follow-upChest wallTissue expanderImplant-based breast reconstructionImmediate prosthetic reconstructionPostmastectomy radiation therapyCompare quality-of-lifeMedian follow-upImplant-based reconstructionPost-operative infectionPlacement of tissue expandersMulticenter randomized trialQuality-of-life scoresSide effects of treatmentStage 0-III breast cancerPhysical well-being scores
2022
Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None?
Moran M, Ho A. Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None? Journal Of Clinical Oncology 2022, 40: 4166-4172. PMID: 36332170, DOI: 10.1200/jco.22.01751.Peer-Reviewed Original ResearchConceptsWide local excisionPartial breast irradiationBreast cancerRadiation therapyEstrogen receptor-positive/progesteroneLow-risk breast cancerOncology Grand Rounds seriesHuman epidermal growth factor receptor 2Left-sided breast cancerWhole breast radiation therapyEpidermal growth factor receptor 2Clinical-pathologic featuresPostmenopausal female patientsDose/fractionationGrowth factor receptor 2Sentinel node biopsyOmission of radiationCommon clinical scenariosFactor receptor 2Node biopsyPostoperative radiationLocal excisionFemale patientsBreast irradiationTreatment recommendations
2017
Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer
Moran M. Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer. 2017, 151-170. DOI: 10.1007/978-3-319-59198-8_9.Peer-Reviewed Original ResearchBreast cancerMutation carriersRadiation therapyLocal-regional managementPost-mastectomy settingBreast conservation therapyBRCA mutation carriersTreatment management decisionsBRCA mutation statusHereditary breast cancerBreast conservationTNBC patientsConservation therapyBRCA carriersFamily historyMutation statusRadiation therapy deliveryTreatment conceptGenetic testingBRCA genesCancerTherapyStrong associationTherapy deliveryPresent guidelines
2016
Radiation Boost for Ductal Carcinoma In Situ After Whole-Breast Radiation Therapy (WBRT) Improves Local Control: Analysis From 10 Pooled Academic Institutions
Moran M, Zhao Y, Ma S, Kirova Y, Fourquet A, Chen P, Hoffman K, Hunt K, Wong J, Halasz L, Freedman G, Prosnitz R, Yassa M, Nguyen D, Hijal T, Haffty B, Wai E, Truong P. Radiation Boost for Ductal Carcinoma In Situ After Whole-Breast Radiation Therapy (WBRT) Improves Local Control: Analysis From 10 Pooled Academic Institutions. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s144. DOI: 10.1016/j.ijrobp.2016.06.349.Peer-Reviewed Original Research
2015
Radiation therapy in the locoregional treatment of triple-negative breast cancer
Moran MS. Radiation therapy in the locoregional treatment of triple-negative breast cancer. The Lancet Oncology 2015, 16: e113-e122. PMID: 25752562, DOI: 10.1016/s1470-2045(14)71104-0.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkers, TumorDecision Support TechniquesDose Fractionation, RadiationFemaleGenetic Predisposition to DiseaseHumansMastectomyNeoplasm Recurrence, LocalPatient SelectionPhenotypePredictive Value of TestsRadiation ToleranceRadiotherapy, AdjuvantRisk AssessmentRisk FactorsTreatment OutcomeTriple Negative Breast Neoplasms
2014
Nomogram for Predicting the Risk of Locoregional Recurrence in Patients Treated With Accelerated Partial-Breast Irradiation
Wobb JL, Chen PY, Shah C, Moran MS, Shaitelman SF, Vicini FA, Mbah AK, Lyden M, Beitsch P. Nomogram for Predicting the Risk of Locoregional Recurrence in Patients Treated With Accelerated Partial-Breast Irradiation. International Journal Of Radiation Oncology • Biology • Physics 2014, 91: 312-318. PMID: 25446607, DOI: 10.1016/j.ijrobp.2014.09.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsBrachytherapyBreast NeoplasmsDose Fractionation, RadiationFemaleHumansMiddle AgedNeoplasm Recurrence, LocalNomogramsOrgan Sparing TreatmentsOutcome Assessment, Health CarePrognosisReproducibility of ResultsRisk AssessmentSensitivity and SpecificityUnited StatesConceptsLocoregional recurrencePartial breast irradiationConcordance indexBreast Surgeons MammoSite Registry TrialCox proportional hazards regression modelRisk of LRREarly-stage breast cancerProportional hazards regression modelsAccelerated Partial Breast IrradiationEstrogen receptor negativityBalloon-based brachytherapyHazards regression modelsWilliam Beaumont HospitalConformal radiation therapyBias-corrected indicesReceptor negativityRegistry trialClinicopathologic featuresPositive marginsClinicopathologic variablesBeaumont HospitalUnivariate analysisBreast cancerUse nomogramRadiation therapy
2013
Should Low-Risk Patients Be Treated With Three-Dimensional Conformal Radiation Therapy–Accelerated Partial-Breast Irradiation in an Off-Protocol Setting?
Moran MS. Should Low-Risk Patients Be Treated With Three-Dimensional Conformal Radiation Therapy–Accelerated Partial-Breast Irradiation in an Off-Protocol Setting? Journal Of Clinical Oncology 2013, 31: 4032-4037. PMID: 24081936, DOI: 10.1200/jco.2013.51.1642.Peer-Reviewed Original ResearchThe Relative Benefits of Tamoxifen in Older Women with T1 Early‐Stage Breast Cancer Treated with Breast‐Conserving Surgery and Radiation Therapy
Khan AJ, Parikh RR, Neboori HJ, Goyal S, Haffty BG, Moran MS. The Relative Benefits of Tamoxifen in Older Women with T1 Early‐Stage Breast Cancer Treated with Breast‐Conserving Surgery and Radiation Therapy. The Breast Journal 2013, 19: 490-495. PMID: 23800027, DOI: 10.1111/tbj.12150.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalLocal relapse-free survivalUse of tamoxifenOverall survivalBreast relapseBreast cancerRadiation therapyOlder womenHormone receptor-positive breast carcinomaElderly breast cancer patientsNode-negative breast cancerEarly-stage breast cancerLow local recurrence rateInstitutional data baseIpsilateral breast relapseT1N0M0 breast cancerAdjuvant hormonal therapyAdjuvant radiation therapyBreast conserving surgeryContralateral breast cancerLocal recurrence rateBreast-conserving surgeryMetastasis-free survivalRelapse-free survivalBreast cancer patients
2012
Analysis of coronary artery dosimetry in the 3-dimensional era: Implications for organ-at-risk segmentation and dose tolerances in left-sided tangential breast radiation
Evans SB, Panigrahi B, Northrup V, Patterson J, Baldwin DE, Higgins SA, Moran MS. Analysis of coronary artery dosimetry in the 3-dimensional era: Implications for organ-at-risk segmentation and dose tolerances in left-sided tangential breast radiation. Practical Radiation Oncology 2012, 3: e55-e60. PMID: 24674321, DOI: 10.1016/j.prro.2012.06.007.Peer-Reviewed Original ResearchMean LAD doseLAD doseBreast radiationLAD arteryLeft-sided breast cancer patientsLeft main coronary arteryHeart dose constraintsMean heart doseTangential radiation therapyAnterior descending (LAD) arteryMain coronary arteryBreast cancer patientsHeart V10Heart V25Proximal LADHeart doseStudy cohortCoronary arteryCancer patientsMean doseRadiation therapyDose correlatesDose constraintsArteryPercent increaseMulti-Institutional Experience of Ductal Carcinoma In Situ in Black vs White Patients Treated With Breast-Conserving Surgery and Whole Breast Radiation Therapy
Nelson C, Bai H, Neboori H, Takita C, Motwani S, Wright JL, Hobeika G, Haffty BG, Jones T, Goyal S, Moran MS. Multi-Institutional Experience of Ductal Carcinoma In Situ in Black vs White Patients Treated With Breast-Conserving Surgery and Whole Breast Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2012, 84: e279-e283. PMID: 22672752, DOI: 10.1016/j.ijrobp.2012.03.068.Peer-Reviewed Original ResearchConceptsWhole breast radiation therapyLocal relapse-free survivalRelapse-free survivalBreast-conserving surgeryBreast radiation therapyDCIS patientsRadiation therapyBreast conservationBlack patientsDuctal carcinomaRacial disparitiesUniversity-based cancer centerSignificant overall survival differenceFunction of raceAdjuvant radiation therapyBreast conserving surgeryOverall survival differenceEstrogen receptor statusMulti-institutional cohortMulti-institutional experiencePositive margin rateSignificant racial differencesTreatment delivery parametersPaucity of dataHormonal therapyA Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer
Moran MS, Ma S, Jagsi R, Yang TJ, Higgins SA, Weidhaas JB, Wilson LD, Lloyd S, Peschel R, Gaudreau B, Rockwell S. A Prospective, Multicenter Study of Complementary/Alternative Medicine (CAM) Utilization During Definitive Radiation for Breast Cancer. International Journal Of Radiation Oncology • Biology • Physics 2012, 85: 40-46. PMID: 22658441, DOI: 10.1016/j.ijrobp.2012.03.025.Peer-Reviewed Original ResearchConceptsBreast cancer patientsAlternative medicine utilizationCancer patientsBreast cancerCAM practicesDefinitive radiationCAM usersMedicine utilizationBreast patientsFirst prospective studyRadiation therapy useMulti-institutional studyOral CAMYounger patientsTherapy useCAM useStudy cohortCAM usageMulticenter studyProspective studyCAM utilizationStage 0Radiation therapyPatientsMultivariate analysis
2011
DEAD box 1 (DDX1) Expression Predicts for Local Control and Overall Survival in Early-stage, Node-negative Breast Cancer Treated with Breast Conserving Surgery and Radiation Therapy
Taunk N, Goyal S, Wu H, Moran M, Chen S, Haffty B. DEAD box 1 (DDX1) Expression Predicts for Local Control and Overall Survival in Early-stage, Node-negative Breast Cancer Treated with Breast Conserving Surgery and Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s63-s64. DOI: 10.1016/j.ijrobp.2011.06.128.Peer-Reviewed Original ResearchInterferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) as a Prognostic Marker for Local Control in T1-2 N0 Breast Cancer Treated with Breast Conserving Surgery and Radiation Therapy (BCS+RT)
Danish H, Goyal S, Taunk N, Wu H, Moran M, Haffty B. Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) as a Prognostic Marker for Local Control in T1-2 N0 Breast Cancer Treated with Breast Conserving Surgery and Radiation Therapy (BCS+RT). International Journal Of Radiation Oncology • Biology • Physics 2011, 81: s214. DOI: 10.1016/j.ijrobp.2011.06.394.Peer-Reviewed Original ResearchA prospective, multicenter trial of complementary and alternative medicine (CAM) utilization by patients undergoing definitive breast radiotherapy.
Moran M, Yang J, Ma S, Gaudreau B, Higgins S, Weidhaas J, Wilson L, Peschel R, Fass D, Rockwell S. A prospective, multicenter trial of complementary and alternative medicine (CAM) utilization by patients undergoing definitive breast radiotherapy. Journal Of Clinical Oncology 2011, 29: 241-241. DOI: 10.1200/jco.2011.29.27_suppl.241.Peer-Reviewed Original ResearchCAM useRadiation therapyStage 0Relaxation/stress reductionTreatment-related symptomsLarge prospective studiesChance of cureAlternative medicine utilizationUtilization of CAMPaucity of dataYounger ptsStudy nursesMulticenter trialSymptom reliefProspective studyBreast radiotherapySkin assessmentHigh prevalenceMedicine utilizationAlternative medicineCAM practicesRT centersAssessment scoresHigher education levelSignificant differencesACR Appropriateness Criteria® Locally Advanced Breast Cancer
MacDonald SM, Harris EE, Arthur DW, Bailey L, Bellon JR, Carey L, Goyal S, Halyard MY, Moran M, Horst K, Haffty BG. ACR Appropriateness Criteria® Locally Advanced Breast Cancer. The Breast Journal 2011, 17: 579-585. PMID: 21906206, DOI: 10.1111/j.1524-4741.2011.01150.x.Peer-Reviewed Original ResearchConceptsAdvanced breast cancerAppropriateness CriteriaBreast cancerRadiation therapyAmerican CollegeAppropriateness of imagingManagement of LABCACR Appropriateness CriteriaRadiology Appropriateness CriteriaEvidence-based guidelinesMultidisciplinary expert panelSpecific clinical conditionsCurrent medical literatureLABC casesPeer-reviewed journalsMultidisciplinary managementBreast reconstructionBreast CommitteeClinical conditionsGuideline developmentIntegration of radiationMedical literatureConsensus methodologyExpert panelTreatment proceduresACR Appropriateness Criteria® Conservative surgery and Radiation – Stage I and II Breast Carcinoma
Bellon JR, Harris EE, Arthur DW, Bailey L, Carey L, Goyal S, Halyard MY, Horst KC, Moran MS, MacDonald SM, Haffty BG. ACR Appropriateness Criteria® Conservative surgery and Radiation – Stage I and II Breast Carcinoma. The Breast Journal 2011, 17: 448-455. PMID: 21790842, DOI: 10.1111/j.1524-4741.2011.01132.x.Peer-Reviewed Original ResearchConceptsRadiation therapySide effectsEarly-stage breast cancerLong-term side effectsAdjuvant radiation therapyAcute side effectsACR Appropriateness CriteriaWhole breast irradiationRisk of recurrenceAtherosclerotic heart diseasePartial breast irradiationMajority of womenConservative surgerySurvival benefitAppropriate patientsBreast conservationRandomized studyAppropriateness CriteriaHeart diseaseBreast carcinomaBreast cancerTherapyShort treatmentEffective alternativeTreatment
2010
Poly(ADP-ribose) polymerase-1 (PARP-1) expression in patients treated with breast-conserving surgery and radiation therapy (BCS+RT).
Goswami J, Goyal S, Wu H, Moran M, Haffty B. Poly(ADP-ribose) polymerase-1 (PARP-1) expression in patients treated with breast-conserving surgery and radiation therapy (BCS+RT). Journal Of Clinical Oncology 2010, 28: 582-582. DOI: 10.1200/jco.2010.28.15_suppl.582.Peer-Reviewed Original Research
2009
Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1
Sharma C, Harris L, Haffty BG, Yang Q, Moran MS. Does Compliance with Radiation Therapy Differ in African‐American Patients with Early‐Stage Breast Cancer?1. The Breast Journal 2009, 16: 193-196. PMID: 20030649, DOI: 10.1111/j.1524-4741.2009.00874.x.Peer-Reviewed Original ResearchConceptsBreast conservation therapyAA patientsWhite patientsWorse outcomesRadiation therapyAfrican American breast cancer patientsEarly-stage breast cancerAdjuvant chemotherapy regimensMedian radiation doseBreast cancer patientsLarge institutional seriesAfrican American patientsDate of treatmentChemotherapy regimenChemotherapy regimensSame radiation dosesChart reviewInstitutional seriesTherapy differsTreatment breaksConservation therapyCancer patientsBreast cancerMedian numberTreatment daysRadiation Techniques and Toxicities for Locally Advanced Breast Cancer
Moran MS, Haffty BG. Radiation Techniques and Toxicities for Locally Advanced Breast Cancer. Seminars In Radiation Oncology 2009, 19: 244-255. PMID: 19732689, DOI: 10.1016/j.semradonc.2009.05.007.Peer-Reviewed Original ResearchClinicopathologic Significance of Excision Repair Cross-Complementation 1 Expression in Patients Treated With Breast-Conserving Surgery and Radiation Therapy
Goyal S, Parikh RR, Green C, Schiff D, Moran MS, Yang Q, Haffty BG. Clinicopathologic Significance of Excision Repair Cross-Complementation 1 Expression in Patients Treated With Breast-Conserving Surgery and Radiation Therapy. International Journal Of Radiation Oncology • Biology • Physics 2009, 76: 679-684. PMID: 19464815, DOI: 10.1016/j.ijrobp.2009.02.050.Peer-Reviewed Original ResearchConceptsDistant metastasis-free survivalHuman epidermal growth factor receptor 2Cause-specific survivalLower T stageMetastasis-free survivalBreast conservation therapyERCC-1 expressionERCC1 expressionAdjuvant chemotherapyHormonal therapyER positivityOverall survivalT stageConservation therapyProgesterone receptorBreast cancerEstrogen receptorNodal negativityRadiation therapyWorse distant metastasis-free survivalEarly-stage breast cancer patientsLocoregional recurrence-free survivalEarly-stage breast cancerEpidermal growth factor receptor 2Adjuvant hormonal therapy