2024
Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications
Talcott W, Marta G, Moran M. Underuse of Postoperative Radiation After Nipple-Sparing Mastectomy for Standard Radiation Indications. Advances In Radiation Oncology 2024, 9: 101569. PMID: 39188995, PMCID: PMC11345291, DOI: 10.1016/j.adro.2024.101569.Peer-Reviewed Original ResearchPost-operative radiationNipple-sparing mastectomyRegional nodal irradiationAdverse pathologic featuresOverall survivalPathological featuresEarly-stage breast cancerNational Cancer DatabasePost-operative settingType of surgeryHigh-risk subgroupsNipple preservationNodal irradiationPN+ ratePositive marginsRadiation deliveryInvasive carcinomaSurgical subtypesCancer DatabaseLymph nodesPatient selectionPN+Breast cancerCox regressionMultivariate analysisReply to G.B. Mann et al and S. Sorscher
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Small W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Reply to G.B. Mann et al and S. Sorscher. Journal Of Clinical Oncology 2024, 42: 1998-2000. PMID: 38489573, DOI: 10.1200/jco.24.00224.Peer-Reviewed Original Research
2023
Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Small W, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Omission of Radiotherapy After Breast-Conserving Surgery for Women With Breast Cancer With Low Clinical and Genomic Risk: 5-Year Outcomes of IDEA. Journal Of Clinical Oncology 2023, 42: 390-398. PMID: 38060195, DOI: 10.1200/jco.23.02270.Peer-Reviewed Original ResearchBreast-conserving surgeryIpsilateral breast eventsEndocrine therapyPostmenopausal patientsBreast cancerCrude rateLower riskBreast cancer-specific survival ratesUnifocal invasive breast cancersYears of ETCancer-specific survival ratesStage I breast cancerHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Omission of radiotherapyYounger postmenopausal patientsPatients age 50Primary end pointBreast conserving surgeryGrowth factor receptor 2I breast cancerInvasive breast cancerRecurrence 5 yearsPatients age 65Single-arm trialPatient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction
Wong J, Uno H, Tramontano A, Pellegrini C, Bellon J, Cheney M, Hardenbergh P, Ho A, Horst K, Kim J, Leonard K, Moran M, Park C, Recht A, Shiloh R, Taghian A, Warren L, Wright J, Chun Y, Punglia R. Patient-Reported and Toxicity Results from the FABREC Study: A Multicenter Randomized Trial of Hypofractionated vs. Conventionally-Fractionated Postmastectomy Radiation Therapy after Implant-Based Reconstruction. International Journal Of Radiation Oncology • Biology • Physics 2023, 117: e3-e4. DOI: 10.1016/j.ijrobp.2023.08.029.Peer-Reviewed Original ResearchPreoperative endocrine therapyCW toxicityEndocrine therapyQuality-of-lifeLymph nodesHF-PMRTRadiation therapyBreast reconstructionRandomized trialsResults Median follow-upChest wallTissue expanderImplant-based breast reconstructionImmediate prosthetic reconstructionPostmastectomy radiation therapyCompare quality-of-lifeMedian follow-upImplant-based reconstructionPost-operative infectionPlacement of tissue expandersMulticenter randomized trialQuality-of-life scoresSide effects of treatmentStage 0-III breast cancerPhysical well-being scoresPhysician’s comfort level with observing ductal carcinoma in situ of the breast: a survey of breast specialists at accredited breast centers in the United States
Poli E, Chang C, Bleicher R, Moran M, Dietz J, Sarantou T, Kurtzman S, Yao K. Physician’s comfort level with observing ductal carcinoma in situ of the breast: a survey of breast specialists at accredited breast centers in the United States. Annals Of Breast Surgery 2023, 0: 0-0. DOI: 10.21037/abs-22-1.Peer-Reviewed Original Research
2022
Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None?
Moran M, Ho A. Radiation Therapy for Low-Risk Breast Cancer: Whole, Partial, or None? Journal Of Clinical Oncology 2022, 40: 4166-4172. PMID: 36332170, DOI: 10.1200/jco.22.01751.Peer-Reviewed Original ResearchConceptsWide local excisionPartial breast irradiationBreast cancerRadiation therapyEstrogen receptor-positive/progesteroneLow-risk breast cancerOncology Grand Rounds seriesHuman epidermal growth factor receptor 2Left-sided breast cancerWhole breast radiation therapyEpidermal growth factor receptor 2Clinical-pathologic featuresPostmenopausal female patientsDose/fractionationGrowth factor receptor 2Sentinel node biopsyOmission of radiationCommon clinical scenariosFactor receptor 2Node biopsyPostoperative radiationLocal excisionFemale patientsBreast irradiationTreatment recommendationsDecreasing the Interval Wait Times for Screening Mammogram Results Using the “Reflex Testing” Algorithm
Alvarenga J, Moran J, Bulgaru A, Moran M. Decreasing the Interval Wait Times for Screening Mammogram Results Using the “Reflex Testing” Algorithm. Journal Of Breast Imaging 2022, 4: 474-479. PMID: 38416949, DOI: 10.1093/jbi/wbac043.Peer-Reviewed Original ResearchFirst diagnostic testReflex testingDiagnostic testsScreening mammogramsBI-RADS 0Date of biopsyAdditional diagnostic testingAbnormal screening mammogramPearson chi-square analysisWait timeAnalytic cohortMammogram resultsSix-month periodBreast centerChi-square analysisDiagnostic testingBiopsyPatientsInterventionCohortDaysMammogramsElapsed daysTestingReflex
2021
85: The Use of Bolus in Postmastectomy Radiation Therapy for Breast Cancer: A Systematic Review
Dahn H, Boersma L, de Ruysscher D, Meattini I, Offersen B, Pignol J, Belkacemi Y, Benjamin D, Bese N, Coles C, Franco P, Ho A, Hol S, Jagsi R, Kirby A, Marrazzo L, Marta G, Moran M, Nichol A, Nissen H, Strnad V, Zissiadis Y, Aristei C, Poortman P, Kaidar-Person O. 85: The Use of Bolus in Postmastectomy Radiation Therapy for Breast Cancer: A Systematic Review. Radiotherapy And Oncology 2021, 163: s38. DOI: 10.1016/s0167-8140(21)08963-5.Peer-Reviewed Original Research54: International Expert Delphi Consensus Guidelines for the Use of Bolus in Post Mastectomy Radiation Therapy
Dahn H, Boersma L, de Ruysscher D, Meattini I, Offersen B, Pignol J, Aristei C, Benjamin D, Bese N, Coles C, Franco P, Ho A, Hol S, Jagsi R, Kirby A, Marrazzo L, Marta G, Moran M, Nichol A, Nissen H, Strnad V, Zissiadis Y, Poortmans P, Kaidar-Person O. 54: International Expert Delphi Consensus Guidelines for the Use of Bolus in Post Mastectomy Radiation Therapy. Radiotherapy And Oncology 2021, 163: s26. DOI: 10.1016/s0167-8140(21)08932-5.Peer-Reviewed Original ResearchASO Visual Abstract: The Impact of Radiotherapy Delay in Breast-Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures
Bleicher R, Moran M, Ruth K, Edge S, Dietz J, Wilke L, Stearns V, Kurtzman S, Klein J, Yao K. ASO Visual Abstract: The Impact of Radiotherapy Delay in Breast-Conservation Patients Not Receiving Chemotherapy and the Rationale for Dichotomizing the Radiation Oncology Time-Dependent Standard into Two Quality Measures. Annals Of Surgical Oncology 2021, 28: 572-573. DOI: 10.1245/s10434-021-10535-8.Peer-Reviewed Original ResearchCLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated
Peters G, Gao S, Knowlton C, Zhang A, Evans S, Higgins S, Wilson L, Saltmarsh N, Picone M, Moran M. CLO21-025: Benefit of Deep Inspiratory Breath Hold for Right Breast Cancer When Regional Lymph Nodes Are Irradiated. Journal Of The National Comprehensive Cancer Network 2021, 19: clo21-025. DOI: 10.6004/jnccn.2020.7707.Peer-Reviewed Original Research
2020
2019
Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features
Jagsi R, Griffith K, Harris E, Wright J, Recht A, Taghian A, Lee L, Moran M, Thomas T, Johnstone C, Rahimi A, Freedman G, Muzaffar M, Haffty B, Horst K, Powell S, Sharp J, Sabel M, Schott A, El-Tamer M. Planned Interim Analysis Results from a Prospective Multicenter Single-Arm Cohort Study of Patients Receiving Endocrine Therapy but Not Radiotherapy after Breast-Conserving Surgery for Early-Stage Breast Cancer with Favorable Biologic Features. International Journal Of Radiation Oncology • Biology • Physics 2019, 105: s7-s8. DOI: 10.1016/j.ijrobp.2019.06.392.Peer-Reviewed Original ResearchPV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB
Chowdhary M, Lee A, Gao S, Barry P, Diaz R, Bagadiya N, Park H, Yu J, Wilson L, Moran M, Higgins S, Knowlton C, Patel K. PV-0045 Is proton therapy a "pro" for breast cancer? A comparison of proton vs. non-proton RT using the NCDB. Radiotherapy And Oncology 2019, 133: s15. DOI: 10.1016/s0167-8140(19)30465-7.Peer-Reviewed Original Research
2018
EP-1328: Impact of deep inspiration breath hold on heart and lung dose constraints in a large breast series
Loganadane G, Kann B, Young M, Knowlton C, Higgins S, Belkacemi Y, Wilson L, Moran M. EP-1328: Impact of deep inspiration breath hold on heart and lung dose constraints in a large breast series. Radiotherapy And Oncology 2018, 127: s727-s728. DOI: 10.1016/s0167-8140(18)31638-4.Peer-Reviewed Original ResearchEP-1321: Incidental radiation dose to the internal mammary chain in a large clinical breast series
Loganadane G, Kann B, Young M, Knowlton C, Evans S, Higgins S, Belkacemi Y, Wilson L, Moran M. EP-1321: Incidental radiation dose to the internal mammary chain in a large clinical breast series. Radiotherapy And Oncology 2018, 127: s724. DOI: 10.1016/s0167-8140(18)31631-1.Peer-Reviewed Original Research
2017
Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer
Moran M. Radiation Oncology Considerations in the Management of Mutation Carriers with Breast Cancer. 2017, 151-170. DOI: 10.1007/978-3-319-59198-8_9.Peer-Reviewed Original ResearchBreast cancerMutation carriersRadiation therapyLocal-regional managementPost-mastectomy settingBreast conservation therapyBRCA mutation carriersTreatment management decisionsBRCA mutation statusHereditary breast cancerBreast conservationTNBC patientsConservation therapyBRCA carriersFamily historyMutation statusRadiation therapy deliveryTreatment conceptGenetic testingBRCA genesCancerTherapyStrong associationTherapy deliveryPresent guidelines
2016
Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ
Morrow M, Van Zee KJ, Solin LJ, Houssami N, Chavez-MacGregor M, Harris JR, Horton J, Hwang S, Johnson PL, Marinovich ML, Schnitt SJ, Wapnir I, Moran MS. Society of Surgical Oncology–American Society for Radiation Oncology–American Society of Clinical Oncology Consensus Guideline on Margins for Breast-Conserving Surgery With Whole-Breast Irradiation in Ductal Carcinoma In Situ. Journal Of Clinical Oncology 2016, 34: 4040-4046. PMID: 27528719, PMCID: PMC5477830, DOI: 10.1200/jco.2016.68.3573.Peer-Reviewed Original ResearchConceptsIpsilateral breast tumor recurrenceWhole breast irradiationRisk of IBTRNegative marginsDuctal carcinomaRate of IBTRSurgical Oncology–American SocietyMargin widthMultidisciplinary consensus panelBreast tumor recurrenceBreast conserving surgeryBreast-conserving surgeryNegative margin widthOptimal negative margin widthRe-excision ratesHealth care costsFurther surgeryPositive marginsBreast irradiationConsensus guidelinesCosmetic outcomeTumor recurrenceClear marginsConsensus panelBackground ControversyRadiation Boost for Ductal Carcinoma In Situ After Whole-Breast Radiation Therapy (WBRT) Improves Local Control: Analysis From 10 Pooled Academic Institutions
Moran M, Zhao Y, Ma S, Kirova Y, Fourquet A, Chen P, Hoffman K, Hunt K, Wong J, Halasz L, Freedman G, Prosnitz R, Yassa M, Nguyen D, Hijal T, Haffty B, Wai E, Truong P. Radiation Boost for Ductal Carcinoma In Situ After Whole-Breast Radiation Therapy (WBRT) Improves Local Control: Analysis From 10 Pooled Academic Institutions. International Journal Of Radiation Oncology • Biology • Physics 2016, 96: s144. DOI: 10.1016/j.ijrobp.2016.06.349.Peer-Reviewed Original ResearchLa Danse d'un Cygne (The Dance of a Swan)
Moran M. La Danse d'un Cygne (The Dance of a Swan). International Journal Of Radiation Oncology • Biology • Physics 2016 DOI: 10.1016/j.ijrobp.2016.06.2451.Peer-Reviewed Original Research