2022
Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans. Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.Peer-Reviewed Original ResearchSubjective drug effectsPlasma Mg concentrationHeart rateDrug effectsIntravenous deliveryNon-menthol cigarette smokersPlacebo-controlled studyTest sessionsCigarette smokersMenthol smokersAcute effectsIntravenous nicotineGlucuronide concentrationsMAIN OUTCOMENicotine infusionMenthol glucuronideSecondary analysisPlasma MgE-cigarettesBehavioral effectsMenthol exposureNicotineSmokersPhysiological effectsE-liquids
2001
Intravenous cocaine increases plasma epinephrine and norepinephrine in humans
Sofuoglu M, Nelson D, Babb D, Hatsukami D. Intravenous cocaine increases plasma epinephrine and norepinephrine in humans. Pharmacology Biochemistry And Behavior 2001, 68: 455-459. PMID: 11325399, DOI: 10.1016/s0091-3057(01)00482-8.Peer-Reviewed Original ResearchConceptsNorepinephrine concentrationsPlasma epinephrineHeart rate changesBlood pressureCocaine injectionHuman studiesPeak plasma epinephrineSympathoadrenal system activationPlacebo-controlled studyDiastolic blood pressureSystolic blood pressureDose of cocaineMale cocaine usersPlasma norepinephrineEpinephrine levelsSympathoadrenal systemCocaine administrationIntravenous injectionSystem activationIntravenous cocaineEpinephrineConsecutive daysNorepinephrineCocaineCocaine users