2022
Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies
De Aquino J, Bahji A, Gómez O, Sofuoglu M. Alleviation of opioid withdrawal by cannabis and delta-9-tetrahydrocannabinol: A systematic review of observational and experimental human studies. Drug And Alcohol Dependence 2022, 241: 109702. PMID: 36434879, PMCID: PMC9772106, DOI: 10.1016/j.drugalcdep.2022.109702.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidCannabinoid Receptor AgonistsCannabinoidsCannabisDronabinolFemaleHallucinogensHumansMaleNarcoticsSubstance Withdrawal SyndromeConceptsOpioid withdrawalObservational studySystematic reviewDelta-9-tetrahydrocannabinol administrationPlacebo-controlled clinical trialCannabis useNon-opioid therapeuticsPotential of cannabinoidsDose of opioidsOpioid withdrawal symptomsOpioid use disorderNarrow therapeutic windowExperimental human studiesDose-dependent increaseMain psychoactive constituentPatient characteristicsWithdrawal symptomsClinical trialsPharmacological factorsStudy qualityTherapeutic windowTherapeutic benefitUse disordersHuman studiesAbuse liabilityEffect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone
Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, Sofuoglu M, Kuzma A, Loughead J, Morrow AL, Epperson CN. Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone. Biology Of Sex Differences 2022, 13: 60. PMID: 36274158, PMCID: PMC9590190, DOI: 10.1186/s13293-022-00472-w.Peer-Reviewed Original ResearchMeSH KeywordsCross-Over StudiesCuesFatigueFemaleHumansNeurosteroidsNicotinePregnanoloneProgesteroneSmokersSmokingSubstance Withdrawal SyndromeConceptsTobacco use disorderProgesterone ratioConversion of progesteroneNicotine withdrawalSmoking cuesTherapeutic effectPlacebo-controlled crossover studySmoking-related outcomesNeural responsesSex-dependent effectsGreater therapeutic benefitDays of abstinenceCrossover studyFemale smokersProgesterone administrationNeurosteroid allopregnanoloneWithdrawal symptomsNicotine effectsWithdrawal severityAllopregnanoloneTherapeutic benefitUse disordersSmoking urgesProgesteroneProgesterone conversionProgesterone Increases Nicotine Withdrawal and Anxiety in Male but Not Female Smokers During Brief Abstinence
Novick AM, Duffy KA, Johnson RL, Sammel MD, Cao W, Strasser AA, Sofuoglu M, Kuzma A, Loughead J, Epperson CN. Progesterone Increases Nicotine Withdrawal and Anxiety in Male but Not Female Smokers During Brief Abstinence. Nicotine & Tobacco Research 2022, 24: 1898-1905. PMID: 35713950, PMCID: PMC9653080, DOI: 10.1093/ntr/ntac146.Peer-Reviewed Original ResearchMeSH KeywordsAnxietyCross-Over StudiesFemaleHumansMaleNicotineProgesteroneSmokersSmoking CessationSubstance Withdrawal SyndromeTobacco Use DisorderConceptsBrief abstinenceNegative affectNicotine withdrawalNicotine use disorderUse disordersFemale smokersNeural measuresFinal drug administrationSmoking cuesSmoking-related outcomesNeural responsesEffect of progesteroneSmoking urgesMood statesSex-dependent effectsSmoking outcomesNicotine effectsDrug AdministrationAbstinence periodSubjective effectsNicotine dependenceAbstinenceMain effectSignificant sexPlacebo-controlled crossover studyDevelopment of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans
De Aquino JP, DeVito EE, Xie C, Meyerovich J, Parida S, Gueorguieva R, Sofuoglu M. Development of pulsed intravenous nicotine infusions as a model for inhaled nicotine in humans. Psychopharmacology 2022, 239: 2809-2818. PMID: 35554617, DOI: 10.1007/s00213-022-06162-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultCross-Over StudiesHeart RateHumansInfusions, IntravenousNicotineSmokersSubstance Withdrawal Syndrome
2021
The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder
De Aquino JP, Parida S, Sofuoglu M. The Pharmacology of Buprenorphine Microinduction for Opioid Use Disorder. Clinical Drug Investigation 2021, 41: 425-436. PMID: 33818748, PMCID: PMC8020374, DOI: 10.1007/s40261-021-01032-7.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineHumansNarcotic AntagonistsOpioid-Related DisordersReceptors, Opioid, muSubstance Withdrawal SyndromeConceptsUnique pharmacological profileOpioid use disorderOpioid withdrawalPotential dose-dependent effectsPlacebo-controlled clinical trialLong-term treatment outcomesFull opioid agonistsStandard induction regimensOpen-label studyFirst-line pharmacotherapySchedule of administrationMu-opioid receptorsAvailability of buprenorphineDose-dependent effectFuture translational researchInduction regimensOpioid taperOpioid toneFirst doseClinical outcomesClinical evidenceOpioid agonistsBuprenorphine formulationsDaily dosesClinical trials
2012
Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine
Sofuoglu M, Herman AI, Nadim H, Jatlow P. Rapid Nicotine Clearance is Associated with Greater Reward and Heart Rate Increases from Intravenous Nicotine. Neuropsychopharmacology 2012, 37: 1509-1516. PMID: 22334123, PMCID: PMC3327855, DOI: 10.1038/npp.2011.336.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnalysis of VarianceCarbon MonoxideChi-Square DistributionChromatography, High Pressure LiquidCotinineDose-Response Relationship, DrugHeart RateHumansHydrocortisoneInjections, IntravenousMaleMiddle AgedNicotineNicotinic AgonistsSingle-Blind MethodSubstance Withdrawal SyndromeTandem Mass SpectrometryTime FactorsYoung AdultConceptsHigher nicotine metabolite ratioNicotine metabolite ratioHeart rate increaseCessation treatmentNicotine clearanceOvernight abstinenceGood drug effectBlood pressure measuresDiastolic blood pressure measuresEffects of nicotinePoor treatment responseNicotine dependence scoresTreatment-seeking smokersGreater heart rate increaseIntravenous dosesNicotine patchPoor outcomeNicotine rewardDrug likingFagerstrom TestTreatment outcomesIntravenous nicotineTreatment responseCigarette cravingHeart rate
1990
Maintenance of morphine dependence by naloxone in acutely dependent mice.
Sofuoglu M, Sato J, Takemori A. Maintenance of morphine dependence by naloxone in acutely dependent mice. Journal Of Pharmacology And Experimental Therapeutics 1990, 254: 841-6. PMID: 2395116.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBehavior, AnimalDrug InteractionsInjections, SubcutaneousMaleMiceMorphine DependenceNaloxoneSubstance Withdrawal SyndromeConceptsMorphine sulfateNaloxone hydrochloridePriming doseED50 valuesSingle doseControl groupMorphine-pretreated miceOpioid antagonist naloxoneSigns of withdrawalDevelopment of dependenceMS injectionDependent miceAntagonist naloxoneMorphine dependenceMiceDoseFormer groupMS 24NaloxoneHrPretreatmentWithdrawalInjectionGroupDays