2018
Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients
Arout CA, Waters AJ, MacLean RR, Compton P, Sofuoglu M. Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients. Psychopharmacology 2018, 236: 2857-2866. PMID: 30564869, PMCID: PMC6581631, DOI: 10.1007/s00213-018-5146-7.Peer-Reviewed Original ResearchConceptsOpioid-induced hyperalgesiaCold pressor testOpioid use disorderSerum cytokinesPain thresholdUse disordersAddiction-related outcomesProinflammatory serum cytokinesActivation of microgliaSeverity of painEcological momentary assessmentEnd of treatmentHuman laboratory studiesTest sessionsOpioid cravingMinocycline treatmentOpioid toleranceAgonist treatmentPain sensitivityVisit 1Minocycline effectsPressor testExperimental painPreclinical studiesGo/No-Go task
2000
Effects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine
Sofuoglu M, Brown S, Babb D, Pentel P, Hatsukami D. Effects of Labetalol Treatment on the Physiological and Subjective Response to Smoked Cocaine. Pharmacology Biochemistry And Behavior 2000, 65: 255-259. PMID: 10672977, DOI: 10.1016/s0091-3057(99)00201-4.Peer-Reviewed Original ResearchConceptsSystolic blood pressureLabetalol treatmentBlood pressureDose of labetalolEffects of labetalolSubjective responsesCocaine deliveryHeart rate increaseCocaine-induced increasesEffect of treatmentCrossover studyMedication treatmentCardiovascular responsesHeart rateAdrenergic receptorsLabetalolSmoked CocaineBehavioral effectsSubjective effectsCocaineDrug labetalolCocaine usersTreatmentDosesExperimental sessions